2'-benzyloxy-3'-bromo-5'-t-butyldimethylsilyloxy-α'-methylbenzyl-2,2,2-trichloroethanimidate

Base Information

Chemical Name:2'-benzyloxy-3'-bromo-5'-t-butyldimethylsilyloxy-α'-methylbenzyl-2,2,2-trichloroethanimidate
CAS No.:843644-62-2
Molecular Formula:C₂₃H₂₉BrCl₃NO₃Si
Molecular Weight:581.837
Hs Code.:

Synonyms:2'-benzyloxy-3'-bromo-5'-t-butyldimethylsilyloxy-α'-methylbenzyl-2,2,2-trichloroethanimidate

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Chemical Property of 2'-benzyloxy-3'-bromo-5'-t-butyldimethylsilyloxy-α'-methylbenzyl-2,2,2-trichloroethanimidate

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Technology Process of 2'-benzyloxy-3'-bromo-5'-t-butyldimethylsilyloxy-α'-methylbenzyl-2,2,2-trichloroethanimidate

There total 6 articles about 2'-benzyloxy-3'-bromo-5'-t-butyldimethylsilyloxy-α'-methylbenzyl-2,2,2-trichloroethanimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 843644-61-1
1-(2'-benzyloxy-3'-bromo-5'-t-butyldimethylsilyloxyphenyl)-ethanol

: 545-06-2
trichloroacetonitrile

: 843644-62-2
2'-benzyloxy-3'-bromo-5'-t-butyldimethylsilyloxy-α'-methylbenzyl-2,2,2-trichloroethanimidate

Guidance literature:: 1-(2'-benzyloxy-3'-bromo-5'-t-butyldimethylsilyloxyphenyl)-ethanol; With sodium hydride; In diethyl ether; at -10 ℃; for 0.166667h;

trichloroacetonitrile; In diethyl ether; at -10 - 20 ℃;
DOI:10.1039/b414213f

Reference yield:

: 843644-58-6
5'-t-butyldimethylsilyloxy-2'-hydroxyacetophenone

: 843644-62-2
2'-benzyloxy-3'-bromo-5'-t-butyldimethylsilyloxy-α'-methylbenzyl-2,2,2-trichloroethanimidate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 96 percent / Br₂; pyridine / CH₂Cl₂ / 3 h / 20 °C

2.1: 97 percent / K₂CO₃ / acetone / 45 °C

3.1: 91 percent / NaBH₄ / ethanol / 1 h / 20 °C

4.1: NaH / diethyl ether / 0.17 h / -10 °C

4.2: 88 percent / diethyl ether / -10 - 20 °C

With pyridine; sodium tetrahydroborate; bromine; sodium hydride; potassium carbonate; In diethyl ether; ethanol; dichloromethane; acetone;
DOI:10.1039/b414213f

Reference yield:

: 843644-60-0
3'-bromo-5'-t-butyldimethylsilyloxy-2'-hydroxyacetophenone

: 843644-62-2
2'-benzyloxy-3'-bromo-5'-t-butyldimethylsilyloxy-α'-methylbenzyl-2,2,2-trichloroethanimidate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 97 percent / K₂CO₃ / acetone / 45 °C

2.1: 91 percent / NaBH₄ / ethanol / 1 h / 20 °C

3.1: NaH / diethyl ether / 0.17 h / -10 °C

3.2: 88 percent / diethyl ether / -10 - 20 °C

With sodium tetrahydroborate; sodium hydride; potassium carbonate; In diethyl ether; ethanol; acetone;
DOI:10.1039/b414213f