2-(dicyanomethylene)-3-cyano-5,5-trimethyl-4-{2-[5-(2-phenylpyrid-4-yl)thien-2-yl]ethen-1-yl}-2,5-dihydrofuran

Base Information

Chemical Name:2-(dicyanomethylene)-3-cyano-5,5-trimethyl-4-{2-[5-(2-phenylpyrid-4-yl)thien-2-yl]ethen-1-yl}-2,5-dihydrofuran
CAS No.:1341232-92-5
Molecular Formula:C₂₇H₁₈N₄OS
Molecular Weight:446.532
Hs Code.:

Synonyms:2-(dicyanomethylene)-3-cyano-5,5-trimethyl-4-{2-[5-(2-phenylpyrid-4-yl)thien-2-yl]ethen-1-yl}-2,5-dihydrofuran

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Chemical Property of 2-(dicyanomethylene)-3-cyano-5,5-trimethyl-4-{2-[5-(2-phenylpyrid-4-yl)thien-2-yl]ethen-1-yl}-2,5-dihydrofuran

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Technology Process of 2-(dicyanomethylene)-3-cyano-5,5-trimethyl-4-{2-[5-(2-phenylpyrid-4-yl)thien-2-yl]ethen-1-yl}-2,5-dihydrofuran

There total 4 articles about 2-(dicyanomethylene)-3-cyano-5,5-trimethyl-4-{2-[5-(2-phenylpyrid-4-yl)thien-2-yl]ethen-1-yl}-2,5-dihydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1341232-91-4
4-(5-formylthien-2-yl)-2-phenylpyridine

: 171082-32-9
2-dicyanomethylidene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran

: 1341232-92-5
2-(dicyanomethylene)-3-cyano-5,5-trimethyl-4-{2-[5-(2-phenylpyrid-4-yl)thien-2-yl]ethen-1-yl}-2,5-dihydrofuran

Guidance literature:: With piperidine; In acetonitrile; at 20 ℃; for 15h; Inert atmosphere;
DOI:10.1002/ejoc.201100651

Reference yield:

: (5-formylthiophen-2-yl)boronic acid

: 1341232-92-5
2-(dicyanomethylene)-3-cyano-5,5-trimethyl-4-{2-[5-(2-phenylpyrid-4-yl)thien-2-yl]ethen-1-yl}-2,5-dihydrofuran

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 20 h / Inert atmosphere; Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 0.33 h / 70 °C / Inert atmosphere; Microwave irradiation

3: piperidine / acetonitrile / 15 h / 20 °C / Inert atmosphere

With piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; acetonitrile; 1: Suzuki coupling / 2: Suzuki coupling / 3: Knoevenagel condensation;
DOI:10.1002/ejoc.201100651

Reference yield:

: 1341232-85-6
2-bromo-4-(5-formylthien-2-yl)pyridine

: 1341232-92-5
2-(dicyanomethylene)-3-cyano-5,5-trimethyl-4-{2-[5-(2-phenylpyrid-4-yl)thien-2-yl]ethen-1-yl}-2,5-dihydrofuran

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 0.33 h / 70 °C / Inert atmosphere; Microwave irradiation

2: piperidine / acetonitrile / 15 h / 20 °C / Inert atmosphere

With piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; acetonitrile; 1: Suzuki coupling / 2: Knoevenagel condensation;
DOI:10.1002/ejoc.201100651