Oxepin, 4,5-dihydro- (7CI,8CI,9CI)

Base Information

• Chemical Name: Oxepin, 4,5-dihydro- (7CI,8CI,9CI)
• CAS No.: 29329-01-9
• Molecular Formula: C₆H₈O
• Molecular Weight: 96.1289
• Mol file: 29329-01-9.mol

Synonyms:Oxepin, 4,5-dihydro- (7CI,8CI,9CI)

Chemical Property of Oxepin, 4,5-dihydro- (7CI,8CI,9CI)

Chemical Property:

• Boiling Point: 113 °C (760 mmHg)
• PSA: 9.23000
• LogP: 1.82420

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Oxepin, 4,5-dihydro- (7CI,8CI,9CI)

There total 7 articles about Oxepin, 4,5-dihydro- (7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

3-oxa-7-thiatricyclo<3.3.0.02,4>octane 7,7-dioxide (84451-43-4) → 4,5-dihydro-oxepin (29329-01-9)

Guidance literature:

at 580 ℃; under 0.001 Torr;

DOI:10.1039/c39820001164

Reference yield:

cyclohex-2-enyl hydroperoxide (4845-05-0) + Tosyl isocyanate (4083-64-1) → 4,5-dihydro-oxepin (29329-01-9) + C14H17NO5S

Guidance literature:

In chloroform-d1; at 0 ℃;

DOI:10.1021/jo00097a006

Reference yield:

peroxyacetic acid cyclohex-2-enyl ester (212964-30-2) → acetic acid-(2,3,4,5-tetrahydro-oxepin-2-yl ester) (95528-48-6) + 4,5-dihydro-oxepin (29329-01-9)

Guidance literature:

With boron trifluoride diethyl etherate; for 0.5h;

DOI:10.1021/jo00097a006

upstream raw materials:

peroxyacetic acid cyclohex-2-enyl ester

cyclohex-2-enyl hydroperoxide

Tosyl isocyanate

exo-6,7-diaza-3-oxatricyclo<3.2.2.0^2,4>non-6-ene

Refernces

Control over the relative stereochemistry at C4 and C5 of 4,5-dihydrooxepins through the cope rearrangement of 2,3-divinyl epoxides and a conformational analysis of this ring system

10.1021/ja00038a032

This research focuses on controlling the relative stereochemistry at C4 and C5 of 4,5-dihydrooxepins through the Cope rearrangement of cis-2,3-divinyl epoxides. The purpose is to develop a method for stereospecific synthesis of both cis and trans isomers of 4,5-disubstituted 4,5-dihydrooxepins, which can be used as precursors for the synthesis of the oxepin portion of the aranotin family of natural products. The researchers used various chemicals including (4E)-cis-2,3-epoxy-5-(trimethylsilyl)-4-pentenal (3), (5E)-cis-3,4-epoxy-6-(trimethylsilyl)-5-hexen-2-one (4), and different phosphonate reagents for the Wadsworth-Homer-Emmons olefination to prepare cis-2,3-divinyl epoxides.