(S)-7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Base Information

Chemical Name:(S)-7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide
CAS No.:497849-79-3
Molecular Formula:C₃₅H₃₇N₃O₅
Molecular Weight:579.696
Hs Code.:

Synonyms:(S)-7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide

There total 6 articles about (S)-7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 497849-77-1
(S)-7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-1-(trifluoroacetyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide

: 497849-79-3
(S)-7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃; for 4h;
DOI:10.1248/cpb.52.818

Reference yield:

: 955-44-2
2-(α-hydroxy-4-nitrobenzyl)pyridine

: 497849-79-3
(S)-7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / H₂ / Pd/C / ethanol; ethyl acetate / 20 °C

2.1: hexane; ethanol

3.1: benzotriazol-1-ol; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 1.5 h / 20 °C

3.2: 71 percent / Et₃N / dimethylformamide / 19 h / 20 °C

4.1: 76 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 20 °C

5.1: 90 percent / NaBH₄ / ethanol / 4 h / 20 °C

With sodium tetrahydroborate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In ethanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.52.818

Reference yield:

: 109-04-6
2-bromo-pyridine

: 497849-79-3
(S)-7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(1-oxidopyridin-2-yl)methyl]phenyl}-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: BuLi / diethyl ether; hexane / 1 h / -78 °C

1.2: 34 percent / diethyl ether; hexane; tetrahydrofuran / 3 h / -78 °C

2.1: 95 percent / H₂ / Pd/C / ethanol; ethyl acetate / 20 °C

3.1: hexane; ethanol

4.1: benzotriazol-1-ol; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 1.5 h / 20 °C

4.2: 71 percent / Et₃N / dimethylformamide / 19 h / 20 °C

5.1: 76 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 20 °C

6.1: 90 percent / NaBH₄ / ethanol / 4 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In diethyl ether; ethanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.52.818