ALPHA-Bromo-2-methylphenylacetic acid

Base Information

• Chemical Name: ALPHA-Bromo-2-methylphenylacetic acid
• CAS No.: 29302-73-6
• Molecular Formula: C9H9 Br O2
• Molecular Weight: 0
• Hs Code.: 2916399090
• Mol file: 29302-73-6.mol

Synonyms:Aceticacid, bromo-o-tolyl- (8CI)

Chemical Property of ALPHA-Bromo-2-methylphenylacetic acid

Chemical Property:

• PSA: 37.30000
• LogP: 2.51560

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ALPHA-Bromo-2-methylphenylacetic acid

There total 5 articles about ALPHA-Bromo-2-methylphenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

o-methylphenylacetic acid (644-36-0) → (+/-)-2-bromo-o-tolyl-acetic acid (29302-73-6)

Guidance literature:

With sulfuric acid; hydrogen bromide; In water; for 3h; Heating;

DOI:10.1016/S0957-4166(01)00432-3

Reference yield: 39.0%

o-methylmandelic acid (85589-35-1) → (+/-)-2-bromo-o-tolyl-acetic acid (29302-73-6)

Guidance literature:

With sulfuric acid; hydrogen bromide; In water; for 3h; Heating;

DOI:10.1016/S0957-4166(02)00784-X

Reference yield:

2-methylphenyl aldehyde (529-20-4) → (+/-)-2-bromo-o-tolyl-acetic acid (29302-73-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium metabisulfite / H₂O

2: HCl / H₂O / 12 h / 20 °C

3: 39 percent / HBr; H₂SO₄ / H₂O / 3 h / Heating

With hydrogenchloride; sodium disulfite; sulfuric acid; hydrogen bromide; In water;

DOI:10.1016/S0957-4166(02)00784-X

upstream raw materials:

o-methylphenylacetic acid

o-methylmandelic acid

2-hydroxy-2-(2-methylphenyl)acetonitrile

2-methylphenyl aldehyde

Downstream raw materials:

(+/-)-2-bromo-2-o-tolylacetic acid benzyl ester

(+/-)-2-bromo-2-o-tolylacetic acid ethyl ester

(+/-)-2-bromo-2-o-tolylacetic acid octyl ester

propyl (+/-)-2-bromo-o-tolyl-acetate

Refernces

• 1、 Guieysse, David,Salagnad, Christophe,Monsan, Pierre,Remaud-Simeon, Magali. "Resolution of 2-bromo-o-tolyl-carboxylic acid by transesterification using lipases from Rhizomucor miehei and Pseudomonas cepacia". . p. 2473 - 2480. Retrieved 2007/10/03.