cyclo(L-Pro-L-Val)

Base Information Edit

Chemical Name:cyclo(L-Pro-L-Val)
CAS No.:2854-40-2
Molecular Formula:C10H16 N2 O2
Molecular Weight:196.249
Hs Code.:2933990090
DSSTox Substance ID:DTXSID40426301
Nikkaji Number:J86.566D
Wikidata:Q27137780
Metabolomics Workbench ID:139427
ChEMBL ID:CHEMBL499570
Mol file:2854-40-2.mol

Synonyms:cyclo(L-Pro-L-Val);cyclo(Pro-Val);cyclo(prolyl-valyl)

Suppliers and Price of cyclo(L-Pro-L-Val)

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Cyclo(L-prolyl-L-valyl)
25mg
$ 335.00

DC Chemicals
Cyclo(L-Pro-L-Val) >98%
1 g
$ 800.00

DC Chemicals
Cyclo(L-Pro-L-Val) >98%
250 mg
$ 400.00

Crysdot
(3S,8AS)-3-isopropylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione 97%
1g
$ 470.00

Cayman Chemical
Cyclo(L-Pro-L-Val)
50mg
$ 55.00

Cayman Chemical
Cyclo(L-Pro-L-Val)
25mg
$ 29.00

Cayman Chemical
Cyclo(L-Pro-L-Val)
100mg
$ 104.00

Cayman Chemical
Cyclo(L-Pro-L-Val)
250mg
$ 232.00

Biosynth Carbosynth
Cyclo(-Pro-Val)
100 mg
$ 300.00

Biosynth Carbosynth
Cyclo(-Pro-Val)
50 mg
$ 200.00

Total 18 raw suppliers

Chemical Property of cyclo(L-Pro-L-Val) Edit

Chemical Property:

Melting Point:190-192 °C
Boiling Point:420.7±34.0 °C(Predicted)
PKA:13.15±0.40(Predicted)
PSA：49.41000
Density:1.17±0.1 g/cm3(Predicted)
LogP:0.39850
Storage Temp.:-15°C
Solubility.:Chloroform (Slightly, Sonicated), Methanol (Slightly)
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:196.121177757
Heavy Atom Count:14
Complexity:275

Purity/Quality:

98.5% ^*data from raw suppliers

Cyclo(L-prolyl-L-valyl) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C1C(=O)N2CCCC2C(=O)N1
Isomeric SMILES:CC(C)[C@H]1C(=O)N2CCC[C@H]2C(=O)N1
Description Cyclo(L-Pro-L-Val) is a diketopiperazine that has been found in the marine sponge T. ignis, the bacterium B. pumilus, and the fungus A. fumigatus, among others. It is active against the bacteria S. aureus and B. subtilis (MICs = 16.3 and 18.2 μg/ml, respectively) but not E. coli (MIC = >20 μg/ml). Cyclo(L-Pro-L-Val) inhibits activation of a LuxR-dependent E. coli biosensor by the quorum-sensing molecule 3-oxo-hexanoyl-homoserine lactone (IC50 = 0.4 mM) and activates violacein pigment production in the LuxR-dependent C. violaceum acyl homoserine lactone reporter strain CV026. However, it does not activate or inhibit lacZ-based reporter fusions in S. liquefaciens or A. tumefaciens.
Uses Cyclo(L-Pro-L-Val) is a diketopiperazine formed by the fusion of valine and proline, reported as a secondary metabolite of fungi and bacteria. In Pseudomonas aeruginosa, cyclo(L-Pro-L-Val) is capable of activating N-acylhomoserine lactones (AHLs). Cyclo(L-Pro-L-Val) is also capable of activating or antagonizing other LuxR-based quorum-sensing systems. While the mode of action of the cyclo(L-Pro-L-Val) is not known, its activity suggests the existence of cross talk among bacterial signalling systems. Cyclo(L-prolyl-L-valyl) is a metabolite found in various marine fungi and bacteria. It is a diketopiperazine derivative isolated from Bacillus thuringiensis and Bacillus endophyticus.

Technology Process of cyclo(L-Pro-L-Val)

There total 29 articles about cyclo(L-Pro-L-Val) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%