1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)propan-1-ol hydrochloride

Base Information

• Chemical Name: 1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)propan-1-ol hydrochloride
• CAS No.: 1394147-51-3
• Molecular Formula: C₂₃H₂₅NOS*ClH
• Molecular Weight: 399.985

Synonyms:1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)propan-1-ol hydrochloride

Chemical Property of 1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)propan-1-ol hydrochloride

Chemical Property:

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Technology Process of 1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)propan-1-ol hydrochloride

There total 3 articles about 1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)propan-1-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)propan-1-one hydrochloride (1394148-06-1) → 1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)propan-1-ol hydrochloride (1394147-51-3)

Guidance literature:

1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)propan-1-one hydrochloride; With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h;

With hydrogenchloride; In ethanol; ethyl acetate; at 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2014.08.045

Reference yield:

4-benzyl-1,2,3,6-tetrahydropyridine hydrochloride (37581-40-1) → 1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)propan-1-ol hydrochloride (1394147-51-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethanol; water / 5 h / Reflux

1.2: 1 h / 20 °C

2.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

3.1: hydrogenchloride / ethanol; ethyl acetate / 1 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; In methanol; ethanol; water; ethyl acetate; 1.1: Mannich reaction;

DOI:10.1016/j.ejmech.2012.04.030

Reference yield:

3-acetylbenzothiophene (1128-05-8) + 4-benzyl-1,2,3,6-tetrahydropyridine hydrochloride (37581-40-1) → 1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)propan-1-ol hydrochloride (1394147-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethanol; ethyl acetate / 6 h / 20 - 80 °C

2.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

2.2: 1 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; In methanol; ethanol; ethyl acetate; 1.1: |Mannich Aminomethylation;

DOI:10.1016/j.ejmech.2014.08.045

upstream raw materials:

1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)propan-1-one hydrochloride

4-benzyl-1,2,3,6-tetrahydropyridine hydrochloride

3-acetylbenzothiophene

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