(R,E)-6-(2-bromo-4-fluorophenyl)-3-(1-hydroxyethylidene)piperidine-2,4-dione

Base Information

• Chemical Name: (R,E)-6-(2-bromo-4-fluorophenyl)-3-(1-hydroxyethylidene)piperidine-2,4-dione
• CAS No.: 1177369-31-1
• Molecular Formula: C₁₃H₁₁BrFNO₃
• Molecular Weight: 328.138

Synonyms:(R,E)-6-(2-bromo-4-fluorophenyl)-3-(1-hydroxyethylidene)piperidine-2,4-dione

Chemical Property of (R,E)-6-(2-bromo-4-fluorophenyl)-3-(1-hydroxyethylidene)piperidine-2,4-dione

Chemical Property:

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Technology Process of (R,E)-6-(2-bromo-4-fluorophenyl)-3-(1-hydroxyethylidene)piperidine-2,4-dione

There total 1 articles about (R,E)-6-(2-bromo-4-fluorophenyl)-3-(1-hydroxyethylidene)piperidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

(R)-ethyl 3-(2-bromo-4-fluorophenyl)-3-(3-oxobutanamido)propanoate (1177369-29-7) → (R,E)-6-(2-bromo-4-fluorophenyl)-3-(1-hydroxyethylidene)piperidine-2,4-dione (1177369-31-1)

Guidance literature:

(R)-ethyl 3-(2-bromo-4-fluorophenyl)-3-(3-oxobutanamido)propanoate; With sodium; In methanol; at 100 ℃; sealed tube;

With ammonium chloride; In dichloromethane; water;

Reference yield: 74.0%

(R,E)-6-(2-bromo-4-fluorophenyl)-3-(1-hydroxyethylidene)piperidine-2,4-dione (1177369-31-1) + [14C]-guanidine hydrochloride → (R)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydro-2-[14C]-pyrido[4,3-d]pyrimidin-5(6H)-one

Guidance literature:

[¹⁴C]-guanidine hydrochloride; With potassium tert-butylate; In methanol; tert-butyl alcohol; for 0.25h;

(R,E)-6-(2-bromo-4-fluorophenyl)-3-(1-hydroxyethylidene)piperidine-2,4-dione; With propylamine; In methanol; tert-butyl alcohol; at 140 ℃; for 1h; under 5250.53 - 6000.6 Torr; Microwave irradiation;

DOI:10.1002/jlcr.3217

Reference yield: 72.0%

acetylguanidine (5699-40-1) + (R,E)-6-(2-bromo-4-fluorophenyl)-3-(1-hydroxyethylidene)piperidine-2,4-dione (1177369-31-1) → (R)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one (934344-61-3)

Guidance literature:

With pyrrolidine; In ethanol; at 160 ℃; for 0.166667h; microwave irradiation;

upstream raw materials:

(R)-ethyl 3-(2-bromo-4-fluorophenyl)-3-(3-oxobutanamido)propanoate

Downstream raw materials:

(R)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one

(R,Z)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydro-2-[14C]-pyrido[4,3-d]pyrimidin-5(6H)-one O-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl oxime

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