(1r,2S,4r,6R)-2,4,6-triaminocyclohexanol trihydrochloride salt

Base Information

• Chemical Name: (1r,2S,4r,6R)-2,4,6-triaminocyclohexanol trihydrochloride salt
• CAS No.: 74538-65-1
• Molecular Formula: C₆H₁₅N₃O*3ClH
• Molecular Weight: 254.587
• Mol file: 74538-65-1.mol

Synonyms:(1r,2S,4r,6R)-2,4,6-triaminocyclohexanol trihydrochloride salt

Chemical Property of (1r,2S,4r,6R)-2,4,6-triaminocyclohexanol trihydrochloride salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1r,2S,4r,6R)-2,4,6-triaminocyclohexanol trihydrochloride salt

There total 8 articles about (1r,2S,4r,6R)-2,4,6-triaminocyclohexanol trihydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(1r,2S,4r,6R)-2,4,6-triazidocyclohexanol (74538-63-9) → (1r,2S,4r,6R)-2,4,6-triaminocyclohexanol trihydrochloride salt (74538-65-1)

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide; In methanol;

DOI:10.1016/S0008-6215(00)85704-3

Reference yield:

(1S,2R,3R,5S)-1,2-anhydro-5-O-tosylcyclohexane-1,2,3,5-tetrol (53398-05-3,53447-96-4,59728-09-5) → (1r,2S,4r,6R)-2,4,6-triaminocyclohexanol trihydrochloride salt (74538-65-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / pyridine / 0 °C

2: 49 percent / sodium azide / dimethylformamide / 1 h / 120 °C

3: 90 percent / H₂, HCl (M) / Adams catalyst / methanol

With hydrogenchloride; sodium azide; hydrogen; platinum(IV) oxide; In pyridine; methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0008-6215(00)85704-3

Reference yield:

(-)-(1S,2R,4R,6R)-1,2-Cyclohexylidenedioxycyclohexane-4,6-diol (53397-94-7) → (1r,2S,4r,6R)-2,4,6-triaminocyclohexanol trihydrochloride salt (74538-65-1)

Guidance literature:

Multi-step reaction with 6 steps

2: acid hydrolysis

3: sodium methoxide / methanol

4: 70 percent / pyridine / 0 °C

5: 49 percent / sodium azide / dimethylformamide / 1 h / 120 °C

6: 90 percent / H₂, HCl (M) / Adams catalyst / methanol

With hydrogenchloride; sodium azide; hydrogen; sodium methylate; platinum(IV) oxide; In pyridine; methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0008-6215(00)85704-3

upstream raw materials:

(1r,2S,4r,6R)-2,4,6-triazidocyclohexanol

(-)-(1S,2R,4R,6R)-1,2-Cyclohexylidenedioxycyclohexane-4,6-diol

C₂₆H₃₂O₈S₂

(1S,2R,3R,5S)-1,2-anhydro-5-O-tosylcyclohexane-1,2,3,5-tetrol