Cyclohexanecarboxylic acid 2,6,7-trioxa-1-phospha-bicyclo[2.2.2]oct-4-ylmethyl ester

Base Information

• Chemical Name: Cyclohexanecarboxylic acid 2,6,7-trioxa-1-phospha-bicyclo[2.2.2]oct-4-ylmethyl ester
• CAS No.: 104501-44-2
• Molecular Formula: C₁₂H₁₉O₅P
• Molecular Weight: 274.254
• Mol file: 104501-44-2.mol

Synonyms:Cyclohexanecarboxylic acid 2,6,7-trioxa-1-phospha-bicyclo[2.2.2]oct-4-ylmethyl ester

Chemical Property of Cyclohexanecarboxylic acid 2,6,7-trioxa-1-phospha-bicyclo[2.2.2]oct-4-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexanecarboxylic acid 2,6,7-trioxa-1-phospha-bicyclo[2.2.2]oct-4-ylmethyl ester

There total 1 articles about Cyclohexanecarboxylic acid 2,6,7-trioxa-1-phospha-bicyclo[2.2.2]oct-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

cyclohexanylcarbonyl chloride (2719-27-9) + 4-hydroxymethyl-1-phospha-2,6,7-trioxabicyclo[2.2.2,]octane (873-93-8) → Cyclohexanecarboxylic acid 2,6,7-trioxa-1-phospha-bicyclo[2.2.2]oct-4-ylmethyl ester (104501-44-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1016/S0040-4039(00)98255-8

Reference yield:

Cyclohexanecarboxylic acid 2,6,7-trioxa-1-phospha-bicyclo[2.2.2]oct-4-ylmethyl ester (104501-44-2) → C12H19O8P (104501-49-7)

Guidance literature:

With ozone; In dichloromethane; at -78 ℃;

DOI:10.1016/S0040-4039(00)98255-8

Reference yield:

Cyclohexanecarboxylic acid 2,6,7-trioxa-1-phospha-bicyclo[2.2.2]oct-4-ylmethyl ester (104501-44-2) → Cyclohexanecarboxylic acid 1-oxo-2,6,7-trioxa-1λ5-phospha-bicyclo[2.2.2]oct-4-ylmethyl ester (104501-53-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ozone / CH₂Cl₂ / -78 °C

2: tetraphenylcyclopentadienone / CH₂Cl₂ / 12 °C / addition at -78 deg C, further reagent: rubrene

With ozone; 2,3,4,5-tetraphenylcyclopenta-2,4-dienone; In dichloromethane;

DOI:10.1016/S0040-4039(00)98255-8

upstream raw materials:

cyclohexanylcarbonyl chloride

4-hydroxymethyl-1-phospha-2,6,7-trioxabicyclo[2.2.2,]octane

Downstream raw materials:

C₁₂H₁₉O₈P

Cyclohexanecarboxylic acid 1-oxo-2,6,7-trioxa-1λ⁵-phospha-bicyclo[2.2.2]oct-4-ylmethyl ester