N,N'-(5,5'-(cyclobutane-1,3-diylbis(methylene))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide)

Base Information

Chemical Name:N,N'-(5,5'-(cyclobutane-1,3-diylbis(methylene))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide)
CAS No.:1610726-25-4
Molecular Formula:C₂₆H₂₆N₆O₂S₂
Molecular Weight:518.663
Hs Code.:

Synonyms:N,N'-(5,5'-(cyclobutane-1,3-diylbis(methylene))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide)

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Chemical Property of N,N'-(5,5'-(cyclobutane-1,3-diylbis(methylene))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide)

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Technology Process of N,N'-(5,5'-(cyclobutane-1,3-diylbis(methylene))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide)

There total 6 articles about N,N'-(5,5'-(cyclobutane-1,3-diylbis(methylene))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15760-35-7
3-methylenecyclobutanecarbonitrile

: 1610726-25-4
N,N'-(5,5'-(cyclobutane-1,3-diylbis(methylene))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide)

Guidance literature:: Multi-step reaction with 7 steps

1: potassium hydroxide / water; ethanol / 2 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C

3: dimethylsulfide borane complex / tetrahydrofuran / 0 - 20 °C

4: triethylamine / dichloromethane / 12 h / 0 °C

5: N,N-dimethyl-formamide / 12 h / Reflux

6: trifluoroacetic acid / 3 h / 100 °C

7: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C

With lithium aluminium tetrahydride; dimethylsulfide borane complex; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 15760-36-8
3-methylenecyclobutane-1-carboxylic acid

: 1610726-25-4
N,N'-(5,5'-(cyclobutane-1,3-diylbis(methylene))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide)

Guidance literature:: Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C

2: dimethylsulfide borane complex / tetrahydrofuran / 0 - 20 °C

3: triethylamine / dichloromethane / 12 h / 0 °C

4: N,N-dimethyl-formamide / 12 h / Reflux

5: trifluoroacetic acid / 3 h / 100 °C

6: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C

With lithium aluminium tetrahydride; dimethylsulfide borane complex; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 10555-45-0
(3-methylenecyclobutyl)methanol

: 1610726-25-4
N,N'-(5,5'-(cyclobutane-1,3-diylbis(methylene))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide)

Guidance literature:: Multi-step reaction with 5 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 0 - 20 °C

2: triethylamine / dichloromethane / 12 h / 0 °C

3: N,N-dimethyl-formamide / 12 h / Reflux

4: trifluoroacetic acid / 3 h / 100 °C

5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C

With dimethylsulfide borane complex; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;