1,1-dimethylethyl [5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]acetate

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Chemical Name:1,1-dimethylethyl [5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]acetate
CAS No.:1258856-60-8
Molecular Formula:C₂₇H₃₀N₄O₄
Molecular Weight:474.56
Hs Code.:

Synonyms:1,1-dimethylethyl [5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]acetate

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Chemical Property of 1,1-dimethylethyl [5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]acetate

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Technology Process of 1,1-dimethylethyl [5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]acetate

There total 7 articles about 1,1-dimethylethyl [5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1258855-73-0
2-[(1-methylethyl)oxy]-5-[3-(1,2,3,4-tetrahydro-5-isoquinolinyl)-1,2,4-oxadiazol-5-yl]benzonitrile mono-trifluoroacetate

: 1258856-60-8
1,1-dimethylethyl [5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]acetate

Guidance literature:: With potassium carbonate; In acetonitrile; for 3h;

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1258856-60-8
1,1-dimethylethyl [5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / 4 h / 20 °C

2: pyridine / toluene / 3 h / 120 °C / Reflux

3: dichloromethane / 0 - 20 °C

4: potassium carbonate / acetonitrile / 3 h

With pyridine; oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; In dichloromethane; toluene; acetonitrile;

Reference yield:

: 1072948-37-8
3-cyano-4-[(1-methylethyl)oxy]benzoyl chloride

: 1258856-60-8
1,1-dimethylethyl [5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / toluene / 3 h / 120 °C / Reflux

2: dichloromethane / 0 - 20 °C

3: potassium carbonate / acetonitrile / 3 h

With pyridine; potassium carbonate; In dichloromethane; toluene; acetonitrile;