trifluoro-methanesulfonic acid 3,5-dichloro-4-[3-(4,4-difluoro-piperidin-1-yl)-2-oxo-pyrrolidin-1-ylmethyl]-phenyl ester

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Chemical Name:trifluoro-methanesulfonic acid 3,5-dichloro-4-[3-(4,4-difluoro-piperidin-1-yl)-2-oxo-pyrrolidin-1-ylmethyl]-phenyl ester
CAS No.:956319-50-9
Molecular Formula:C₁₇H₁₇Cl₂F₅N₂O₄S
Molecular Weight:511.297
Hs Code.:

Synonyms:trifluoro-methanesulfonic acid 3,5-dichloro-4-[3-(4,4-difluoro-piperidin-1-yl)-2-oxo-pyrrolidin-1-ylmethyl]-phenyl ester

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Chemical Property of trifluoro-methanesulfonic acid 3,5-dichloro-4-[3-(4,4-difluoro-piperidin-1-yl)-2-oxo-pyrrolidin-1-ylmethyl]-phenyl ester

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Technology Process of trifluoro-methanesulfonic acid 3,5-dichloro-4-[3-(4,4-difluoro-piperidin-1-yl)-2-oxo-pyrrolidin-1-ylmethyl]-phenyl ester

There total 2 articles about trifluoro-methanesulfonic acid 3,5-dichloro-4-[3-(4,4-difluoro-piperidin-1-yl)-2-oxo-pyrrolidin-1-ylmethyl]-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1-(2,6-dichloro-4-hydroxy-benzyl)-3-(4,4-difluoro-piperidin-1-yl)-pyrrolidin-2-one

: 358-23-6
trifluoromethylsulfonic anhydride

: 956319-50-9
trifluoro-methanesulfonic acid 3,5-dichloro-4-[3-(4,4-difluoro-piperidin-1-yl)-2-oxo-pyrrolidin-1-ylmethyl]-phenyl ester

Guidance literature:: With pyridine; dmap; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

: 1-(4-benzyloxy-2,6-dichloro-benzyl)-3-(4,4-difluoro-piperidin-1-yl)-pyrrolidin-2-one

: 956319-50-9
trifluoro-methanesulfonic acid 3,5-dichloro-4-[3-(4,4-difluoro-piperidin-1-yl)-2-oxo-pyrrolidin-1-ylmethyl]-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium(II) hydroxide/carbon / tetrahydrofuran; ethyl acetate / 6 h / 20 °C

2: pyridine; dmap / dichloromethane / 2 h / 0 °C

With pyridine; dmap; hydrogen; palladium(II) hydroxide/carbon; In tetrahydrofuran; dichloromethane; ethyl acetate;