Technology Process of (Z)-4-(cyclohex-1-en-1-yl)-1-phenylbut-1-en-3-yn-1-yl acetate
There total 3 articles about (Z)-4-(cyclohex-1-en-1-yl)-1-phenylbut-1-en-3-yn-1-yl acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(Z)-2-bromo-1-phenylethylene acetate;
With
copper(l) iodide; palladium diacetate; triethylamine; triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 0.0833333h;
1-ethenylcyclohexene;
In
tetrahydrofuran;
at 50 ℃;
for 6h;
DOI:10.1021/jo1023987
- Guidance literature:
-
(Z)-1-iodooct-1-en-2-yl benzoate;
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
Sealed tube;
1-ethenylcyclohexene;
With
triethylamine;
In
1,4-dioxane;
at 20 ℃;
for 4h;
Inert atmosphere;
Sealed tube;
Darkness;
DOI:10.1021/acs.joc.6b02712
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: (triphenylphosphine)gold(I) chloride; silver(I) hexafluorophosphate / toluene / 18 h / 20 °C / Inert atmosphere; Sealed tube; Darkness
2.1: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere; Sealed tube
2.2: 4 h / 20 °C / Inert atmosphere; Sealed tube; Darkness
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); silver(I) hexafluorophosphate; (triphenylphosphine)gold(I) chloride;
In
1,4-dioxane; toluene;
2.1: |Sonogashira Cross-Coupling / 2.2: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.joc.6b02712
