(R)-5,11,17,23-tetra-tert-butyl-25,27-dihydroxy-26-(3-oxabutyloxy)-28-[(1-phenylethyl)carbamoylmethoxy]calix[4]arene

Base Information

• Chemical Name: (R)-5,11,17,23-tetra-tert-butyl-25,27-dihydroxy-26-(3-oxabutyloxy)-28-[(1-phenylethyl)carbamoylmethoxy]calix[4]arene
• CAS No.: 346001-77-2
• Molecular Formula: C₅₇H₇₃NO₆
• Molecular Weight: 868.21
• Mol file: 346001-77-2.mol

Synonyms:(R)-5,11,17,23-tetra-tert-butyl-25,27-dihydroxy-26-(3-oxabutyloxy)-28-[(1-phenylethyl)carbamoylmethoxy]calix[4]arene

Chemical Property of (R)-5,11,17,23-tetra-tert-butyl-25,27-dihydroxy-26-(3-oxabutyloxy)-28-[(1-phenylethyl)carbamoylmethoxy]calix[4]arene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-5,11,17,23-tetra-tert-butyl-25,27-dihydroxy-26-(3-oxabutyloxy)-28-[(1-phenylethyl)carbamoylmethoxy]calix[4]arene

There total 2 articles about (R)-5,11,17,23-tetra-tert-butyl-25,27-dihydroxy-26-(3-oxabutyloxy)-28-[(1-phenylethyl)carbamoylmethoxy]calix[4]arene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

bromo<(R)-(1-phenylethyl)carbamoyl>methane (166771-57-9) + 5,11,17,23-tetra-tert-butyl-25,26,27-trihydroxy-28-(3-oxabutyloxy)calix[4]arene (346001-76-1) → (R)-5,11,17,23-tetra-tert-butyl-25,27-dihydroxy-26-(3-oxabutyloxy)-28-[(1-phenylethyl)carbamoylmethoxy]calix[4]arene (346001-77-2)

Guidance literature:

5,11,17,23-tetra-tert-butyl-25,26,27-trihydroxy-28-(3-oxabutyloxy)calix[4]arene; With potassium carbonate; In acetonitrile; at 20 ℃; for 2h;

bromo<(R)-(1-phenylethyl)carbamoyl>methane; In acetonitrile; for 48h; Further stages.; Heating;

DOI:10.1039/b009005k

Reference yield:

5,11,17,23-tetra-t-butyl-25,26,27,28-tetrahydroxycalix-4-arene (157432-87-6,288302-11-4,288302-12-5,60705-62-6) → (R)-5,11,17,23-tetra-tert-butyl-25,27-dihydroxy-26-(3-oxabutyloxy)-28-[(1-phenylethyl)carbamoylmethoxy]calix[4]arene (346001-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: K₂CO₃ / acetonitrile / 2 h / 20 °C

1.2: 69 percent / acetonitrile / 120 h / Heating

2.1: K₂CO₃ / acetonitrile / 2 h / 20 °C

2.2: 88 percent / acetonitrile / 48 h / Heating

With potassium carbonate; In acetonitrile;

DOI:10.1039/b009005k

Reference yield: 90.0%

(diphenylphosphoryl)methyl p-toluenesulfonate (33730-69-7) + (R)-5,11,17,23-tetra-tert-butyl-25,27-dihydroxy-26-(3-oxabutyloxy)-28-[(1-phenylethyl)carbamoylmethoxy]calix[4]arene (346001-77-2) → (R)-5,11,17,23-tetra-tert-butyl-25,27-bis[(diphenylphosphinoyl)methoxy]-26-(3-oxabutyloxy)-28-[(1-phenylethyl)carbamoylmethoxy]calix[4]arene (346001-78-3)

Guidance literature:

(R)-5,11,17,23-tetra-tert-butyl-25,27-dihydroxy-26-(3-oxabutyloxy)-28-[(1-phenylethyl)carbamoylmethoxy]calix[4]arene; With sodium hydride; In toluene; at 40 ℃; for 1h;

(diphenylphosphoryl)methyl p-toluenesulfonate; In toluene; at 80 ℃; for 72h; Further stages.;

DOI:10.1039/b009005k

upstream raw materials:

bromo<(R)-(1-phenylethyl)carbamoyl>methane

5,11,17,23-tetra-tert-butyl-25,26,27-trihydroxy-28-(3-oxabutyloxy)calix[4]arene

5,11,17,23-tetra-t-butyl-25,26,27,28-tetrahydroxycalix-4-arene

Downstream raw materials:

(R)-5,11,17,23-tetra-tert-butyl-25,27-bis[(diphenylphosphinoyl)methoxy]-26-(3-oxabutyloxy)-28-[(1-phenylethyl)carbamoylmethoxy]calix[4]arene