3β-(4-chlorophenyl)tropane-2β-N-3-bromophenacylcarboxthioamide ethylene ketal

Base Information

Chemical Name:3β-(4-chlorophenyl)tropane-2β-N-3-bromophenacylcarboxthioamide ethylene ketal
CAS No.:947594-61-8
Molecular Formula:C₂₅H₂₈BrClN₂O₂S
Molecular Weight:535.933
Hs Code.:

Synonyms:3β-(4-chlorophenyl)tropane-2β-N-3-bromophenacylcarboxthioamide ethylene ketal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3β-(4-chlorophenyl)tropane-2β-N-3-bromophenacylcarboxthioamide ethylene ketal

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Technology Process of 3β-(4-chlorophenyl)tropane-2β-N-3-bromophenacylcarboxthioamide ethylene ketal

There total 5 articles about 3β-(4-chlorophenyl)tropane-2β-N-3-bromophenacylcarboxthioamide ethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 947594-60-7
3β-(4-chlorophenyl)tropane-2β-N-3-bromophenacylcarboxamide ethylene ketal

: 947594-61-8
3β-(4-chlorophenyl)tropane-2β-N-3-bromophenacylcarboxthioamide ethylene ketal

Guidance literature:: 3β-(4-chlorophenyl)tropane-2β-N-3-bromophenacylcarboxamide ethylene ketal; With pyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -45 - 0 ℃;

With hydrogen sulfide; In dichloromethane; at 0 ℃; Further stages.;
DOI:10.1021/jm0703035

Reference yield:

: 947594-62-9
3-bromophenacyl azide ethylene ketal

: 947594-61-8
3β-(4-chlorophenyl)tropane-2β-N-3-bromophenacylcarboxthioamide ethylene ketal

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine / tetrahydrofuran

1.2: 95 percent / water / tetrahydrofuran

2.1: 28 percent / 1-hydroxy-7-azabenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 25 °C

3.1: triflic anhydride; pyridine / CH₂Cl₂ / -45 - 0 °C

3.2: 42 percent / hydrogen sulfide / CH₂Cl₂ / 0 °C

With pyridine; 1-hydroxy-7-aza-benzotriazole; trifluoromethylsulfonic anhydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Staudinger reaction;
DOI:10.1021/jm0703035

Reference yield:

: 947594-63-0
3-bromophenacylamine ethylene ketal

: 947594-61-8
3β-(4-chlorophenyl)tropane-2β-N-3-bromophenacylcarboxthioamide ethylene ketal

Guidance literature:: Multi-step reaction with 2 steps

1.1: 28 percent / 1-hydroxy-7-azabenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 25 °C

2.1: triflic anhydride; pyridine / CH₂Cl₂ / -45 - 0 °C

2.2: 42 percent / hydrogen sulfide / CH₂Cl₂ / 0 °C

With pyridine; 1-hydroxy-7-aza-benzotriazole; trifluoromethylsulfonic anhydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0703035