Technology Process of 1,2-dibromo-4-fluoro-3-iodobenzene
There total 1 articles about 1,2-dibromo-4-fluoro-3-iodobenzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1,2,-dibromo-4-fluorobenzene;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
With
iodine;
In
tetrahydrofuran;
for 0.5h;
- Guidance literature:
-
1,2-dibromo-4-fluoro-3-iodobenzene;
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine;
In
tetrahydrofuran;
for 0.166667h;
Sealed tube;
Sonication;
trimethylsilylacetylene;
In
tetrahydrofuran;
at 40 ℃;
for 40h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 0.17 h / Sealed tube; Sonication
1.2: 40 h / 40 °C
2.1: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl acetamide / 26.16 h / 100 °C / Sealed tube; Sonication
3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 18 h / 20 °C / Sealed tube; Inert atmosphere
3.2: 30 h / 60 °C
With
bis-triphenylphosphine-palladium(II) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); copper(l) iodide; diisopropylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; N,N-dimethyl acetamide; dimethyl sulfoxide;
