(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-[(2S)-1-oxo-4-phenyl-1-[4-(2,2,2-trifluoroacetyl)piperazin-1-yl]butan-2-yl]oxolane-2-carboxamide

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Chemical Name:(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-[(2S)-1-oxo-4-phenyl-1-[4-(2,2,2-trifluoroacetyl)piperazin-1-yl]butan-2-yl]oxolane-2-carboxamide
CAS No.:1414799-05-5
Molecular Formula:C₂₆H₂₉F₃N₈O₆
Molecular Weight:606.561
Hs Code.:

Synonyms:(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-[(2S)-1-oxo-4-phenyl-1-[4-(2,2,2-trifluoroacetyl)piperazin-1-yl]butan-2-yl]oxolane-2-carboxamide

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Chemical Property of (2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-[(2S)-1-oxo-4-phenyl-1-[4-(2,2,2-trifluoroacetyl)piperazin-1-yl]butan-2-yl]oxolane-2-carboxamide

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Technology Process of (2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-[(2S)-1-oxo-4-phenyl-1-[4-(2,2,2-trifluoroacetyl)piperazin-1-yl]butan-2-yl]oxolane-2-carboxamide

There total 5 articles about (2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-[(2S)-1-oxo-4-phenyl-1-[4-(2,2,2-trifluoroacetyl)piperazin-1-yl]butan-2-yl]oxolane-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: C₂₉H₃₃F₃N₈O₆

: 1414799-05-5
(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-[(2S)-1-oxo-4-phenyl-1-[4-(2,2,2-trifluoroacetyl)piperazin-1-yl]butan-2-yl]oxolane-2-carboxamide

Guidance literature:: With formic acid; In water; at 70 ℃; for 2h;
DOI:10.1080/15257770.2013.866243

Reference yield:

: 362-75-4
2',3'-isopropylidene adenosine

: 1414799-05-5
(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-[(2S)-1-oxo-4-phenyl-1-[4-(2,2,2-trifluoroacetyl)piperazin-1-yl]butan-2-yl]oxolane-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: [bis(acetoxy)iodo]benzene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile; water / 3 h

2: HATU; N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere

3: sodium hydroxide / water; 1,4-dioxane / 1 h

4: HATU; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

5: formic acid / water / 2 h / 70 °C

With formic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In 1,4-dioxane; water; acetonitrile;
DOI:10.1080/15257770.2013.866243

Reference yield:

: 19234-66-3
2',3'-isopropylideneadenosine-5'-carboxylic acid

: 1414799-05-5
(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-N-[(2S)-1-oxo-4-phenyl-1-[4-(2,2,2-trifluoroacetyl)piperazin-1-yl]butan-2-yl]oxolane-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: HATU; N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere

2: sodium hydroxide / water; 1,4-dioxane / 1 h

3: HATU; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

4: formic acid / water / 2 h / 70 °C

With formic acid; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In 1,4-dioxane; water; acetonitrile;
DOI:10.1080/15257770.2013.866243