(1RS,1'RS,5SR,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-5-ol

Base Information

Chemical Name:(1RS,1'RS,5SR,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-5-ol
CAS No.:122334-23-0
Molecular Formula:C₃₁H₄₁O₄P
Molecular Weight:508.638
Hs Code.:

Synonyms:(1RS,1'RS,5SR,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-5-ol

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Chemical Property of (1RS,1'RS,5SR,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-5-ol

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Technology Process of (1RS,1'RS,5SR,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-5-ol

There total 8 articles about (1RS,1'RS,5SR,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 122334-21-8
(1RS,1'RS,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyl-1,2,3,6,7,7a-hexahydro-5H-inden-5-one

: 122334-23-0
(1RS,1'RS,5SR,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-5-ol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -50 ℃;
DOI:10.1021/jo00282a038

Reference yield:

: 1120-73-6
2-methyl-2-cyclopenten-1-one

: 122334-23-0
(1RS,1'RS,5SR,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-5-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, hexane, -60 deg C, 10 min, 2.) -20 deg C to -15 deg C, 5 min

2: H₂, pyridine / 10percent Pd/C / ethyl acetate / 22 h / 1965.2 Torr

3: 2percent potassium hydroxide / methanol / 2 h / Heating

4: 75 percent / diisobutylaluminum hydride (DIBAL-H) / CH₂Cl₂ / -50 °C

With pyridine; potassium hydroxide; n-butyllithium; hydrogen; diisobutylaluminium hydride; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo00282a038

Reference yield:

: 17668-60-9
trans-crotyldiphenylphosphine oxide

: 122334-23-0
(1RS,1'RS,5SR,7aRS)-4-<(1''',3'''-dioxan-2'''-yl)methyl>-1-<3'-(diphenylphosphinoyl)-1'-methylpropyl>-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-5-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, hexane, -60 deg C, 10 min, 2.) -20 deg C to -15 deg C, 5 min

2: H₂, pyridine / 10percent Pd/C / ethyl acetate / 22 h / 1965.2 Torr

3: 2percent potassium hydroxide / methanol / 2 h / Heating

4: 75 percent / diisobutylaluminum hydride (DIBAL-H) / CH₂Cl₂ / -50 °C

With pyridine; potassium hydroxide; n-butyllithium; hydrogen; diisobutylaluminium hydride; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo00282a038