N⁶-benzoyl-9-(5'-O-tert-butyldiphenylsilyl-2'-deoxy-α-D-erythro-pentofuranosyl)adenine

Base Information

• Chemical Name: N⁶-benzoyl-9-(5'-O-tert-butyldiphenylsilyl-2'-deoxy-α-D-erythro-pentofuranosyl)adenine
• CAS No.: 858672-62-5
• Molecular Formula: C₃₃H₃₅N₅O₄Si
• Molecular Weight: 593.758
• Mol file: 858672-62-5.mol

Synonyms:N⁶-benzoyl-9-(5'-O-tert-butyldiphenylsilyl-2'-deoxy-α-D-erythro-pentofuranosyl)adenine

Chemical Property of N⁶-benzoyl-9-(5'-O-tert-butyldiphenylsilyl-2'-deoxy-α-D-erythro-pentofuranosyl)adenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-benzoyl-9-(5'-O-tert-butyldiphenylsilyl-2'-deoxy-α-D-erythro-pentofuranosyl)adenine

There total 2 articles about N⁶-benzoyl-9-(5'-O-tert-butyldiphenylsilyl-2'-deoxy-α-D-erythro-pentofuranosyl)adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

N-benzoyladenine (4005-49-6) + 6-N-benzoyl-5'-O-tert-butyldiphenylsilyl-2'-deoxy-N-6-benzoyladenosine (139244-35-2) → N6-benzoyl-9-(5'-O-tert-butyldiphenylsilyl-2'-deoxy-α-D-erythro-pentofuranosyl)adenine (858672-62-5)

Guidance literature:

N-benzoyladenine; With tin(IV) chloride; In 1,2-dichloro-ethane; at 0 ℃; for 0.166667h;

6-N-benzoyl-5'-O-tert-butyldiphenylsilyl-2'-deoxy-N-6-benzoyladenosine; In 1,2-dichloro-ethane; at 0 ℃; for 1h;

DOI:10.1081/NCN-200040627

Reference yield:

N6-benzoyl-2'-deoxyadenosine (4546-72-9) → N6-benzoyl-9-(5'-O-tert-butyldiphenylsilyl-2'-deoxy-α-D-erythro-pentofuranosyl)adenine (858672-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 75 percent / pyridine; imidazole / 20 °C

2.1: tin tetrachloride / 1,2-dichloro-ethane / 0.17 h / 0 °C

2.2: 50 percent / 1,2-dichloro-ethane / 1 h / 0 °C

With pyridine; 1H-imidazole; tin(IV) chloride; In 1,2-dichloro-ethane;

DOI:10.1081/NCN-200040627

Reference yield:

N6-benzoyl-9-(5'-O-tert-butyldiphenylsilyl-2'-deoxy-α-D-erythro-pentofuranosyl)adenine (858672-62-5) → 9-(5'-O-tert-butyldiphenylsilyl-2'-deoxy-α-D-erythro-pentofuranosyl)adenine (858672-63-6)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 72h;

DOI:10.1081/NCN-200040627

upstream raw materials:

N-benzoyladenine

6-N-benzoyl-5'-O-tert-butyldiphenylsilyl-2'-deoxy-N-6-benzoyladenosine

N₆-benzoyl-2'-deoxyadenosine

Downstream raw materials:

9-(5'-O-tert-butyldiphenylsilyl-2'-deoxy-α-D-erythro-pentofuranosyl)adenine

α-deoxyadenosine