(S)-1-(2-(tert-butyldimethylsilyloxy)-1 (3-chlorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one

Base Information

Chemical Name:(S)-1-(2-(tert-butyldimethylsilyloxy)-1 (3-chlorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one
CAS No.:1453853-20-7
Molecular Formula:C₂₄H₃₀ClN₃O₄SSi
Molecular Weight:520.124
Hs Code.:

Synonyms:(S)-1-(2-(tert-butyldimethylsilyloxy)-1 (3-chlorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one

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Chemical Property of (S)-1-(2-(tert-butyldimethylsilyloxy)-1 (3-chlorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one

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Technology Process of (S)-1-(2-(tert-butyldimethylsilyloxy)-1 (3-chlorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one

There total 5 articles about (S)-1-(2-(tert-butyldimethylsilyloxy)-1 (3-chlorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1453853-18-3
(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(3-chlorophenyl)ethyl)-4-(2-(methylthio)pyrimidin-4-yl)pyridin-2(1H)-one

: 1453853-20-7
(S)-1-(2-(tert-butyldimethylsilyloxy)-1 (3-chlorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 2h; Cooling with ice;

Reference yield:

: 959236-97-6
4-bromo-2-methylsulfanylpyrimidine

: 1453853-20-7
(S)-1-(2-(tert-butyldimethylsilyloxy)-1 (3-chlorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 2 h / 85 °C / Inert atmosphere

2.1: hydrogenchloride / water / 2 h / Reflux

2.2: 20 °C / pH 7 / Cooling with ice

3.1: potassium hexamethylsilazane / tetrahydrofuran; 2-methyltetrahydrofuran / 0.25 h / 20 °C / Cooling with ice

3.2: 48 h / 80 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium hexamethylsilazane; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1.1: |Suzuki Coupling;

Reference yield:

: 401815-98-3
2-fluoropyridin-4-ylboronic acid

: 1453853-20-7
(S)-1-(2-(tert-butyldimethylsilyloxy)-1 (3-chlorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 2 h / 85 °C / Inert atmosphere

2.1: hydrogenchloride / water / 2 h / Reflux

2.2: 20 °C / pH 7 / Cooling with ice

3.1: potassium hexamethylsilazane / tetrahydrofuran; 2-methyltetrahydrofuran / 0.25 h / 20 °C / Cooling with ice

3.2: 48 h / 80 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium hexamethylsilazane; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1.1: |Suzuki Coupling;