(S)-2,2-diethyl-4-(2-(4-methoxybenzyloxy)ethyl)-1,3-dioxolane

Base Information

• Chemical Name: (S)-2,2-diethyl-4-(2-(4-methoxybenzyloxy)ethyl)-1,3-dioxolane
• CAS No.: 1460293-40-6
• Molecular Formula: C₁₇H₂₆O₄
• Molecular Weight: 294.391
• Mol file: 1460293-40-6.mol

Synonyms:(S)-2,2-diethyl-4-(2-(4-methoxybenzyloxy)ethyl)-1,3-dioxolane

Chemical Property of (S)-2,2-diethyl-4-(2-(4-methoxybenzyloxy)ethyl)-1,3-dioxolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2,2-diethyl-4-(2-(4-methoxybenzyloxy)ethyl)-1,3-dioxolane

There total 1 articles about (S)-2,2-diethyl-4-(2-(4-methoxybenzyloxy)ethyl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(4S)-4-(2-hydroxyethyl)-2,2-diethyl-1,3-dioxolane (90941-88-1) + p-Methoxybenzyl bromide (2746-25-0) → (S)-2,2-diethyl-4-(2-(4-methoxybenzyloxy)ethyl)-1,3-dioxolane (1460293-40-6)

Guidance literature:

(4S)-4-(2-hydroxyethyl)-2,2-diethyl-1,3-dioxolane; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.5h;

p-Methoxybenzyl bromide; With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 6h;

DOI:10.1039/c3ob41569d

Reference yield: 90.0%

(S)-2,2-diethyl-4-(2-(4-methoxybenzyloxy)ethyl)-1,3-dioxolane (1460293-40-6) → (2S)-4-[(4-methoxybenzyl)oxy]butane-1,2-diol (193416-58-9)

Guidance literature:

(S)-2,2-diethyl-4-(2-(4-methoxybenzyloxy)ethyl)-1,3-dioxolane; With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 5h;

With water; In methanol; at 20 ℃; for 4h;

DOI:10.1039/c3ob41569d

Reference yield:

(S)-2,2-diethyl-4-(2-(4-methoxybenzyloxy)ethyl)-1,3-dioxolane (1460293-40-6) → (S)-2-hydroxy-4-(4-methoxybenzyloxy)butyl 2,4,6-triisopropylbenzenesulfonate (195257-57-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / methanol / 5 h / 20 °C

1.2: 4 h / 20 °C

2.1: triethylamine / dichloromethane / 36 h / 20 °C

With toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane;

DOI:10.1039/c3ob41569d

upstream raw materials:

(4S)-4-(2-hydroxyethyl)-2,2-diethyl-1,3-dioxolane

p-Methoxybenzyl bromide

Downstream raw materials:

(2S)-4-[(4-methoxybenzyl)oxy]butane-1,2-diol

(S)-2-hydroxy-4-(4-methoxybenzyloxy)butyl 2,4,6-triisopropylbenzenesulfonate

(2S)-2-[2-(p-methoxybenzyloxy)ethyl]oxirane

(S)-(1-(1,3-dithian-2-yl)-4-(4-methoxybenzyloxy)butan-2-yloxy)(tert-butyl)dimethylsilane