Technology Process of C35H39FO4
There total 13 articles about C35H39FO4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
caesium carbonate;
In
dimethyl sulfoxide;
at 23 ℃;
for 16h;
Concentration;
Time;
Inert atmosphere;
Large scale;
DOI:10.1021/ml300427u
- Guidance literature:
-
Multi-step reaction with 5 steps
1: caesium carbonate / N,N-dimethyl-formamide / 23 h / 20 °C / Inert atmosphere
2: potassium tert-butylate / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
3: 2,6-bis((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)pyridine; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 / tetrahydrofuran / 8 h / 60 °C / Inert atmosphere
4: hydrogen; palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / Inert atmosphere
5: caesium carbonate / dimethyl sulfoxide / 16 h / 23 °C / Inert atmosphere; Large scale
With
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; caesium carbonate; 2,6-bis((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)pyridine;
In
tetrahydrofuran; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml300427u
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dirhodium(II) tetracarboxylate / dichloromethane / 3 h / 20 - 45 °C / Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3: ChiralPak AD / hexane; isopropyl alcohol / Resolution of racemate; Inert atmosphere
4: caesium carbonate / dimethyl sulfoxide / 16 h / 23 °C / Inert atmosphere; Large scale
With
dirhodium(II) tetracarboxylate; tetrabutyl ammonium fluoride; caesium carbonate;
In
tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1021/ml300427u
