methyl (S)-2-chloro-2-{2-[5-fluoro-(2-vinylpyrrolidin-1-yl)carbonyl]phenylhydrazono}acetate

Base Information

Chemical Name:methyl (S)-2-chloro-2-{2-[5-fluoro-(2-vinylpyrrolidin-1-yl)carbonyl]phenylhydrazono}acetate
CAS No.:866915-64-2
Molecular Formula:C₁₆H₁₇ClFN₃O₃
Molecular Weight:353.781
Hs Code.:

Synonyms:methyl (S)-2-chloro-2-{2-[5-fluoro-(2-vinylpyrrolidin-1-yl)carbonyl]phenylhydrazono}acetate

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Chemical Property of methyl (S)-2-chloro-2-{2-[5-fluoro-(2-vinylpyrrolidin-1-yl)carbonyl]phenylhydrazono}acetate

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Technology Process of methyl (S)-2-chloro-2-{2-[5-fluoro-(2-vinylpyrrolidin-1-yl)carbonyl]phenylhydrazono}acetate

There total 4 articles about methyl (S)-2-chloro-2-{2-[5-fluoro-(2-vinylpyrrolidin-1-yl)carbonyl]phenylhydrazono}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 866915-56-2
(S)-(2-amino-5-fluorophenyl)-(2-vinylpyrrolidin-1-yl)methanone

: 4755-81-1,935731-92-3
methyl 2-chloroacetoacetate

: 866915-64-2
methyl (S)-2-chloro-2-{2-[5-fluoro-(2-vinylpyrrolidin-1-yl)carbonyl]phenylhydrazono}acetate

Guidance literature:: (S)-(2-amino-5-fluorophenyl)-(2-vinylpyrrolidin-1-yl)methanone; With hydrogenchloride; sodium nitrite; In methanol; at 5 ℃; for 0.5h;

methyl 2-chloroacetoacetate; In methanol; water; at 20 ℃;
DOI:10.1055/s-2005-869991

Reference yield:

: 866915-52-8
(S)-(2-nitro-5-fluorophenyl)-(2-vinylpyrrolidin-1-yl)methanone

: 866915-64-2
methyl (S)-2-chloro-2-{2-[5-fluoro-(2-vinylpyrrolidin-1-yl)carbonyl]phenylhydrazono}acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 92 percent / Fe; aq. AcOH / ethanol / 5 h / Heating

2.1: NaNO₂; aq. HCl / methanol / 0.5 h / 5 °C

2.2: 84 percent / methanol; H₂O / 20 °C

With hydrogenchloride; iron; acetic acid; sodium nitrite; In methanol; ethanol;
DOI:10.1055/s-2005-869991

Reference yield:

: 146405-59-6
(S)-2-vinylpyrrolidine

: 866915-64-2
methyl (S)-2-chloro-2-{2-[5-fluoro-(2-vinylpyrrolidin-1-yl)carbonyl]phenylhydrazono}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 53 percent / K₂CO₃ / tetrahydrofuran / 4 h / Heating

2.1: 92 percent / Fe; aq. AcOH / ethanol / 5 h / Heating

3.1: NaNO₂; aq. HCl / methanol / 0.5 h / 5 °C

3.2: 84 percent / methanol; H₂O / 20 °C

With hydrogenchloride; iron; potassium carbonate; acetic acid; sodium nitrite; In tetrahydrofuran; methanol; ethanol;
DOI:10.1055/s-2005-869991