7-<<4-(1-(allyloxycarbonyl)piperidin-4-yloxy)phenyl>(ethoxycarbonyl)methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Base Information

Chemical Name:7-<<4-(1-(allyloxycarbonyl)piperidin-4-yloxy)phenyl>(ethoxycarbonyl)methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
CAS No.:218922-87-3
Molecular Formula:C₃₃H₄₂N₂O₈
Molecular Weight:594.705
Hs Code.:

7-<<4-(1-(allyloxycarbonyl)piperidin-4-yloxy)phenyl>(ethoxycarbonyl)methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Synonyms:7-<<4-(1-(allyloxycarbonyl)piperidin-4-yloxy)phenyl>(ethoxycarbonyl)methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-<<4-(1-(allyloxycarbonyl)piperidin-4-yloxy)phenyl>(ethoxycarbonyl)methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 7-<<4-(1-(allyloxycarbonyl)piperidin-4-yloxy)phenyl>(ethoxycarbonyl)methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

There total 12 articles about 7-<<4-(1-(allyloxycarbonyl)piperidin-4-yloxy)phenyl>(ethoxycarbonyl)methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 187265-40-3
4-hydroxypiperidine-1-carboxylic acid allyl ester

: 188576-51-4
7-<(ethoxycarbonyl)(4-hydroxyphenyl)methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

: 218922-87-3
7-<<4-(1-(allyloxycarbonyl)piperidin-4-yloxy)phenyl>(ethoxycarbonyl)methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 72h; Ambient temperature;
DOI:10.1021/jm9800402

Reference yield:

: 7651-83-4
isoquinolin-7-ol

: 218922-87-3
7-<<4-(1-(allyloxycarbonyl)piperidin-4-yloxy)phenyl>(ethoxycarbonyl)methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / H₂, glacial AcOH / PtO₂ / 48 h / Ambient temperature

2: 89 percent / Et₃N / CH₂Cl₂ / 1 h / 5 °C

3: 98 percent / K₂CO₃ / acetonitrile / 24 h / Heating

4: 91 percent / H₂ / 10 percent Pd/C / ethyl acetate / 3 h / Ambient temperature

5: 90 percent / diethyl azodicarboxylate, Ph₃P / tetrahydrofuran / 72 h / Ambient temperature

With hydrogen; potassium carbonate; acetic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jm9800402

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 218922-87-3
7-<<4-(1-(allyloxycarbonyl)piperidin-4-yloxy)phenyl>(ethoxycarbonyl)methoxy>-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / aq. NH₄Cl / diethyl ether / 24 h / 5 °C

2: 88 percent / HCl / diethyl ether / 24 h / 5 °C

3: 85 percent / PCl₅ / CH₂Cl₂ / 24 h / Ambient temperature

4: 98 percent / K₂CO₃ / acetonitrile / 24 h / Heating

5: 91 percent / H₂ / 10 percent Pd/C / ethyl acetate / 3 h / Ambient temperature

6: 90 percent / diethyl azodicarboxylate, Ph₃P / tetrahydrofuran / 72 h / Ambient temperature

With hydrogenchloride; phosphorus pentachloride; hydrogen; potassium carbonate; ammonium chloride; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jm9800402