2,3,3-Trimethyl-1-methylselanylmethyl-2-p-tolyl-cyclobutanol

Base Information

• Chemical Name: 2,3,3-Trimethyl-1-methylselanylmethyl-2-p-tolyl-cyclobutanol
• CAS No.: 85090-94-4
• Molecular Formula: C₁₆H₂₄OSe
• Molecular Weight: 311.326
• Mol file: 85090-94-4.mol

Synonyms:2,3,3-Trimethyl-1-methylselanylmethyl-2-p-tolyl-cyclobutanol

Chemical Property of 2,3,3-Trimethyl-1-methylselanylmethyl-2-p-tolyl-cyclobutanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,3-Trimethyl-1-methylselanylmethyl-2-p-tolyl-cyclobutanol

There total 4 articles about 2,3,3-Trimethyl-1-methylselanylmethyl-2-p-tolyl-cyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2,3,3-Trimethyl-2-p-tolyl-cyclobutanone (85090-93-3) + C2H5LiSe (59554-52-8) → 2,3,3-Trimethyl-1-methylselanylmethyl-2-p-tolyl-cyclobutanol (85090-94-4)

Guidance literature:

In diethyl ether; at -78 ℃; for 1h;

DOI:10.1016/S0040-4039(00)85608-7

Reference yield:

1-(1-Bromo-2,2-dimethyl-cyclopropyl)-1-p-tolyl-ethanol (85110-22-1) → 2,3,3-Trimethyl-1-methylselanylmethyl-2-p-tolyl-cyclobutanol (85090-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1: t-BuOK / tetrahydrofuran / 20 h / 20 °C

2: 75 percent / diethyl ether / 1 h / -78 °C

With potassium tert-butylate; In tetrahydrofuran; diethyl ether;

DOI:10.1016/S0040-4039(00)85608-7

Reference yield:

para-methylacetophenone (122-00-9) → 2,3,3-Trimethyl-1-methylselanylmethyl-2-p-tolyl-cyclobutanol (85090-94-4)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 1 h / -100 °C

2: t-BuOK / tetrahydrofuran / 20 h / 20 °C

3: 75 percent / diethyl ether / 1 h / -78 °C

With potassium tert-butylate; In tetrahydrofuran; diethyl ether;

DOI:10.1016/S0040-4039(00)85608-7

upstream raw materials:

bis(methylseleno)-methane

2,3,3-Trimethyl-2-p-tolyl-cyclobutanone

C₂H₅LiSe

1-(1-Bromo-2,2-dimethyl-cyclopropyl)-1-p-tolyl-ethanol

Downstream raw materials:

1-Chloromethyl-2,3,3-trimethyl-2-p-tolyl-cyclobutanol

4,5,5-Trimethyl-4-p-tolyl-1-oxa-spiro[2.3]hexane