N-((1-(2-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(1H-indol-3-yl)-2-oxoacetamide

Base Information

Chemical Name:N-((1-(2-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(1H-indol-3-yl)-2-oxoacetamide
CAS No.:1456936-31-4
Molecular Formula:C₁₉H₁₄ClN₅O₂
Molecular Weight:379.805
Hs Code.:

Synonyms:N-((1-(2-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(1H-indol-3-yl)-2-oxoacetamide

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Chemical Property of N-((1-(2-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(1H-indol-3-yl)-2-oxoacetamide

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Technology Process of N-((1-(2-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(1H-indol-3-yl)-2-oxoacetamide

There total 3 articles about N-((1-(2-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(1H-indol-3-yl)-2-oxoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 3296-07-9
1-azido-2-chlorobenzene

: 1456936-24-5
2-(1H-indol-3-yl)-2-oxo-N-(prop-2-ynyl)acetamide

: 1456936-31-4
N-((1-(2-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(1H-indol-3-yl)-2-oxoacetamide

Guidance literature:: 2-(1H-indol-3-yl)-2-oxo-N-(prop-2-ynyl)acetamide; With copper(ll) sulfate pentahydrate; In water; tert-butyl alcohol; at 20 ℃; for 0.166667h;

With sodium L-ascorbate; In water; tert-butyl alcohol; for 0.5h;

1-azido-2-chlorobenzene; In water; tert-butyl alcohol; at 20 ℃; for 8h;
DOI:10.1016/j.bioorg.2018.07.029

Reference yield:

: 120-72-9
indole

: 1456936-31-4
N-((1-(2-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(1H-indol-3-yl)-2-oxoacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / 2 h / 20 °C / Inert atmosphere

3: copper(l) iodide; N,N,N',N'',N'''-pentamethyldiethylenetriamine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

With copper(l) iodide; N,N,N',N'',N'''-pentamethyldiethylenetriamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2013.08.064

Reference yield:

: 22980-09-2
indolyl-3-glyoxylyl chloride

: 1456936-31-4
N-((1-(2-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(1H-indol-3-yl)-2-oxoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 2 h / 20 °C / Inert atmosphere

2: copper(l) iodide; N,N,N',N'',N'''-pentamethyldiethylenetriamine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

With copper(l) iodide; N,N,N',N'',N'''-pentamethyldiethylenetriamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2013.08.064