(-)-2-(R)-allyl-2-<(4-methoxybenzyl)carboxamido>pyrrolidine

Base Information

• Chemical Name: (-)-2-(R)-allyl-2-<(4-methoxybenzyl)carboxamido>pyrrolidine
• CAS No.: 116005-51-7
• Molecular Formula: C₁₆H₂₂N₂O₂
• Molecular Weight: 274.363
• Mol file: 116005-51-7.mol

Synonyms:(-)-2-(R)-allyl-2-<(4-methoxybenzyl)carboxamido>pyrrolidine

Chemical Property of (-)-2-(R)-allyl-2-<(4-methoxybenzyl)carboxamido>pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (-)-2-(R)-allyl-2-<(4-methoxybenzyl)carboxamido>pyrrolidine

There total 1 articles about (-)-2-(R)-allyl-2-<(4-methoxybenzyl)carboxamido>pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(2R,5R)-5-allyl-2-tert-butyl-1-aza-3-oxabicyclo<3.3.0>octan-4-one (81286-83-1) + p-methoxybenzylamine lithium → (-)-2-(R)-allyl-2-<(4-methoxybenzyl)carboxamido>pyrrolidine (116005-51-7)

Guidance literature:

In tetrahydrofuran;

DOI:10.1021/ja00225a069

Reference yield:

(-)-2-(R)-allyl-2-<(4-methoxybenzyl)carboxamido>pyrrolidine (116005-51-7) → (-)-2,5-diketo-6-(R)-(formylmethyl)-4-(4-methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane (116051-29-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) K₂CO₃, 2.) NaOH / 1.) CH₂Cl₂, 2.) CH₂Cl₂

2: 99 percent / O₃ / methanol

With sodium hydroxide; potassium carbonate; ozone; In methanol;

DOI:10.1021/ja00225a069

Reference yield:

(-)-2-(R)-allyl-2-<(4-methoxybenzyl)carboxamido>pyrrolidine (116005-51-7) → 6-<(2E)-4-hydroxy-3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane (116051-30-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) K₂CO₃, 2.) NaOH / 1.) CH₂Cl₂, 2.) CH₂Cl₂

2: 99 percent / O₃ / methanol

3: 2.) NaBH₄ / 2.) EtOH

With sodium hydroxide; sodium tetrahydroborate; potassium carbonate; ozone; In methanol;

DOI:10.1021/ja00225a069

upstream raw materials:

(2R,5R)-5-allyl-2-tert-butyl-1-aza-3-oxabicyclo<3.3.0>octan-4-one

Downstream raw materials:

(-)-2,5-diketo-6-(R)-allyl-4-(methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

(-)-2,5-diketo-6-(R)-(formylmethyl)-4-(4-methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

6-<(2E)-4-hydroxy-3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

(+)-6-(R)-<(2E)-4-<(tert-butyldimethylsilyl)oxy>3-methylbut-2-enyl>-3-(R)(carbometoxy)-2,5-diketo-3-<(3-indolyl)methyl>-4-(4-methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane