4-((7-((3,4-difluorobenzyl)amino)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzonitrile

Base Information

Chemical Name:4-((7-((3,4-difluorobenzyl)amino)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzonitrile
CAS No.:1370706-07-2
Molecular Formula:C₂₅H₂₃F₂N₃O₂
Molecular Weight:435.473
Hs Code.:

Synonyms:4-((7-((3,4-difluorobenzyl)amino)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzonitrile

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Chemical Property of 4-((7-((3,4-difluorobenzyl)amino)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzonitrile

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Technology Process of 4-((7-((3,4-difluorobenzyl)amino)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzonitrile

There total 7 articles about 4-((7-((3,4-difluorobenzyl)amino)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₁F₂N₃O₂

: 1370706-07-2
4-((7-((3,4-difluorobenzyl)amino)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzonitrile

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2012.01.059

Reference yield:

: 1056737-05-3
(2,4-dimethyl-7-nitro-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methanol

: 1370706-07-2
4-((7-((3,4-difluorobenzyl)amino)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 48 h / Reflux

2: palladium on carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C

3: sodium triacetoxyborohydride / 1,2-dichloro-ethane / 6 h / 20 °C

With sodium triacetoxyborohydride; di-isopropyl azodicarboxylate; palladium on carbon; hydrogen; triphenylphosphine; In tetrahydrofuran; 1,2-dichloro-ethane; 1: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2011.06.089

Reference yield:

: 1056737-14-4
4-[(2,4-dimethyl-7-nitro-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy]benzonitrile

: 1370706-07-2
4-((7-((3,4-difluorobenzyl)amino)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C

2: sodium triacetoxyborohydride / 1,2-dichloro-ethane / 6 h / 20 °C

With sodium triacetoxyborohydride; palladium on carbon; hydrogen; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2011.06.089