N-(p-methoxyphenyl)-O-(tetrahydro-2'H-pyran-2'-yl)-N-trifluoroacetyl-α-vinylalaninol

Base Information

Chemical Name:N-(p-methoxyphenyl)-O-(tetrahydro-2'H-pyran-2'-yl)-N-trifluoroacetyl-α-vinylalaninol
CAS No.:882048-51-3
Molecular Formula:C₁₉H₂₄F₃NO₄
Molecular Weight:387.399
Hs Code.:

Synonyms:N-(p-methoxyphenyl)-O-(tetrahydro-2'H-pyran-2'-yl)-N-trifluoroacetyl-α-vinylalaninol

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Chemical Property of N-(p-methoxyphenyl)-O-(tetrahydro-2'H-pyran-2'-yl)-N-trifluoroacetyl-α-vinylalaninol

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Technology Process of N-(p-methoxyphenyl)-O-(tetrahydro-2'H-pyran-2'-yl)-N-trifluoroacetyl-α-vinylalaninol

There total 3 articles about N-(p-methoxyphenyl)-O-(tetrahydro-2'H-pyran-2'-yl)-N-trifluoroacetyl-α-vinylalaninol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: (E)-3-methyl-4-[(tetrahydro-2'H-pyran-2'-yl)oxy]-2-buten-1-yl N-(p-methoxyphenyl)-trifluoroacetimidate

: 882048-51-3
N-(p-methoxyphenyl)-O-(tetrahydro-2'H-pyran-2'-yl)-N-trifluoroacetyl-α-vinylalaninol

Guidance literature:: With bis(benzonitrile)palladium(II) dichloride; In benzene; at 20 ℃; for 1h;
DOI:10.1021/ol060019s

Reference yield:

: 114978-89-1
4-<(tetrahydro-2H-pyran-2-yl)oxy>-3-methyl-2E-buten-1-ol

: 882048-51-3
N-(p-methoxyphenyl)-O-(tetrahydro-2'H-pyran-2'-yl)-N-trifluoroacetyl-α-vinylalaninol

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / n-butyllithium / tetrahydrofuran / 5.5 h / -78 °C

2: 92 percent / PdCl₂(PhCN)2 / benzene / 1 h / 20 °C

With bis(benzonitrile)palladium(II) dichloride; n-butyllithium; In tetrahydrofuran; benzene;
DOI:10.1021/ol060019s

Reference yield:

: 75999-66-5
(Z)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidoyl chloride

: 882048-51-3
N-(p-methoxyphenyl)-O-(tetrahydro-2'H-pyran-2'-yl)-N-trifluoroacetyl-α-vinylalaninol

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / n-butyllithium / tetrahydrofuran / 5.5 h / -78 °C

2: 92 percent / PdCl₂(PhCN)2 / benzene / 1 h / 20 °C

With bis(benzonitrile)palladium(II) dichloride; n-butyllithium; In tetrahydrofuran; benzene;
DOI:10.1021/ol060019s