5-{2-[4-(iminomorpholin-4-ylmethyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]dec-8-yl}-5-oxopentanoic acid ethyl ester

Base Information

Chemical Name:5-{2-[4-(iminomorpholin-4-ylmethyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]dec-8-yl}-5-oxopentanoic acid ethyl ester
CAS No.:685545-08-8
Molecular Formula:C₂₆H₃₆N₄O₅
Molecular Weight:484.596
Hs Code.:

Synonyms:5-{2-[4-(iminomorpholin-4-ylmethyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]dec-8-yl}-5-oxopentanoic acid ethyl ester

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Chemical Property of 5-{2-[4-(iminomorpholin-4-ylmethyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]dec-8-yl}-5-oxopentanoic acid ethyl ester

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Technology Process of 5-{2-[4-(iminomorpholin-4-ylmethyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]dec-8-yl}-5-oxopentanoic acid ethyl ester

There total 13 articles about 5-{2-[4-(iminomorpholin-4-ylmethyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]dec-8-yl}-5-oxopentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 685544-42-7
5-[2-(4-methylsulfanylcarbonimidoyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-5-oxo-pentanoic acid ethyl ester

: 685545-08-8
5-{2-[4-(iminomorpholin-4-ylmethyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]dec-8-yl}-5-oxopentanoic acid ethyl ester

Guidance literature:: With acetic acid; In methanol; at 20 ℃; for 20h;
DOI:10.1021/jm030354b

Reference yield:

: 5205-39-0
ethyl glutaroyl chloride

: 685545-08-8
5-{2-[4-(iminomorpholin-4-ylmethyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]dec-8-yl}-5-oxopentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / DIEA / dimethylformamide / 4 h / 20 °C

2: H₂S (gas); Et₃N; pyridine / 20 °C

3: acetone / 20 °C

4: AcOH / methanol / 20 h / 20 °C

With pyridine; hydrogen sulfide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm030354b

Reference yield:

: 34702-66-4
8-benzyl-2-oxa-8-aza-spiro[4.5]decane-1,3-dione

: 685545-08-8
5-{2-[4-(iminomorpholin-4-ylmethyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]dec-8-yl}-5-oxopentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: Et₃N / dimethylformamide / 20 °C

2.1: 3.40 g / acetic anhydride; NaOAc / 2 h / Heating

3.1: NaBH₄ / methanol / 0 - 20 °C

3.2: NaBH₄; TFA / 0 - 20 °C

3.3: 792 mg / acetonitrile; CH₂Cl₂ / 20 °C

4.1: 74 percent / aq. NH₄OAc; Cd-Pb couple / tetrahydrofuran / 20 °C

5.1: 92 percent / DIEA / dimethylformamide / 4 h / 20 °C

6.1: H₂S (gas); Et₃N; pyridine / 20 °C

7.1: acetone / 20 °C

8.1: AcOH / methanol / 20 h / 20 °C

With pyridine; sodium tetrahydroborate; 10% Cd/Pd; hydrogen sulfide; ammonium acetate; sodium acetate; acetic anhydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm030354b