(S)-4-i-propyl-5,5-dimethyl-3-[(SP)-methyl(phenyl)phosphinoyll]oxazolidin-2-one

Base Information

Chemical Name:(S)-4-i-propyl-5,5-dimethyl-3-[(SP)-methyl(phenyl)phosphinoyll]oxazolidin-2-one
CAS No.:1346528-88-8
Molecular Formula:C₁₅H₂₂NO₃P
Molecular Weight:295.318
Hs Code.:

Synonyms:(S)-4-i-propyl-5,5-dimethyl-3-[(SP)-methyl(phenyl)phosphinoyll]oxazolidin-2-one

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Chemical Property of (S)-4-i-propyl-5,5-dimethyl-3-[(SP)-methyl(phenyl)phosphinoyll]oxazolidin-2-one

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Technology Process of (S)-4-i-propyl-5,5-dimethyl-3-[(SP)-methyl(phenyl)phosphinoyll]oxazolidin-2-one

There total 7 articles about (S)-4-i-propyl-5,5-dimethyl-3-[(SP)-methyl(phenyl)phosphinoyll]oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 5761-97-7
methyl(phenyl)phosphinic chloride

: 168297-86-7
(S)-4-isopropyl-5,5-dimethyloxazolidin-2-one

: 1346528-87-7
(S)-4-i-propyl-5,5-dimethyl-3-[(RP)-methyl(phenyl)phosphinoyll]oxazolidin-2-one

: 1346528-88-8
(S)-4-i-propyl-5,5-dimethyl-3-[(SP)-methyl(phenyl)phosphinoyll]oxazolidin-2-one

Guidance literature:: With methylmagnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 18h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol202916j

Reference yield:

: 1346528-87-7
(S)-4-i-propyl-5,5-dimethyl-3-[(RP)-methyl(phenyl)phosphinoyll]oxazolidin-2-one

: 1346528-88-8
(S)-4-i-propyl-5,5-dimethyl-3-[(SP)-methyl(phenyl)phosphinoyll]oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium / tetrahydrofuran / Inert atmosphere; Reflux

1.2: 0 °C / Inert atmosphere

2.1: methylmagnesium bromide / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

With methylmagnesium bromide; magnesium; In tetrahydrofuran;
DOI:10.1021/ol202916j

Reference yield:

: 2946-61-4
phenylphosphonous acid dimethyl ester

: 1346528-87-7
(S)-4-i-propyl-5,5-dimethyl-3-[(RP)-methyl(phenyl)phosphinoyll]oxazolidin-2-one

: 1346528-88-8
(S)-4-i-propyl-5,5-dimethyl-3-[(SP)-methyl(phenyl)phosphinoyll]oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 18 h / Inert atmosphere; Reflux

2: phosphorus pentachloride / 1,2-dichloro-ethane / 40 °C / Inert atmosphere

3: methylmagnesium bromide / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

With phosphorus pentachloride; methylmagnesium bromide; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1021/ol202916j