2-amino-4-(4-chlorophenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile

Base Information

• Chemical Name: 2-amino-4-(4-chlorophenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile
• CAS No.: 340812-15-9
• Molecular Formula: C₁₉H₁₅ClN₄
• Molecular Weight: 334.808
• Mol file: 340812-15-9.mol

Synonyms:2-amino-4-(4-chlorophenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile

Chemical Property of 2-amino-4-(4-chlorophenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-amino-4-(4-chlorophenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile

There total 1 articles about 2-amino-4-(4-chlorophenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 4-chlorobenzaldehyde (104-88-1) + malononitrile (109-77-3) → 2-amino-4-(4-chlorophenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile (340812-15-9)

Guidance literature:

With C₂₈H₁₆CoN₁₂O₁₂S₄⁽⁴⁺⁾*4Cl^(1-); In neat (no solvent); at 90 ℃; for 0.166667h;

DOI:10.1039/d0ra02172e

Reference yield: 93.0%

2-amino-4-(4-chlorophenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile (340812-15-9) → 2-amino-4-(4chloro-phenyl)-5,6,7,8-tetrahydro-naphthalene-1,3-dicarbonitrile (141811-23-6)

Guidance literature:

With sodium hydroxide; In water; for 0.0333333h; Sonication;

DOI:10.1016/j.tet.2016.02.023

upstream raw materials:

cyclohexanone

4-chlorobenzaldehyde

malononitrile

Downstream raw materials:

2-amino-4-(4chloro-phenyl)-5,6,7,8-tetrahydro-naphthalene-1,3-dicarbonitrile