2-hydroxy-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1-[4-(trifluoromethoxy)-phenyl]ethanone

Base Information

Chemical Name:2-hydroxy-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1-[4-(trifluoromethoxy)-phenyl]ethanone
CAS No.:1437796-58-1
Molecular Formula:C₂₁H₁₉F₃N₂O₃
Molecular Weight:404.389
Hs Code.:

Synonyms:2-hydroxy-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1-[4-(trifluoromethoxy)-phenyl]ethanone

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Chemical Property of 2-hydroxy-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1-[4-(trifluoromethoxy)-phenyl]ethanone

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Technology Process of 2-hydroxy-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1-[4-(trifluoromethoxy)-phenyl]ethanone

There total 8 articles about 2-hydroxy-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1-[4-(trifluoromethoxy)-phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1418297-39-8
1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)-phenyl]ethane-1,2-dione

: 1418297-40-1
2-hydroxy-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone

: 1437796-58-1
2-hydroxy-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1-[4-(trifluoromethoxy)-phenyl]ethanone

Guidance literature:: With sodium dithionite; water; In N,N-dimethyl-formamide; at 100 ℃; for 1.5h;

Reference yield:

: 20577-61-1
methyl 2,4-dioxopentanoate

: 1418297-40-1
2-hydroxy-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone

: 1437796-58-1
2-hydroxy-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1-[4-(trifluoromethoxy)-phenyl]ethanone

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid / 4 h / 90 °C

2: water; sodium hydroxide / ethanol / 70 °C

3: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 3 h / 0 - 20 °C

4: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1.5 h / -78 °C / Inert atmosphere

5: sodium ethanolate / ethanol / 4 h

6: 4-methylmorpholine N-oxide; osmium(VIII) oxide / acetone; tert-butyl alcohol / 20 °C

7: water; sodium dithionite / N,N-dimethyl-formamide / 1.5 h / 100 °C

With osmium(VIII) oxide; lithium aluminium tetrahydride; sodium dithionite; oxalyl dichloride; water; sodium ethanolate; acetic acid; 4-methylmorpholine N-oxide; sodium hydroxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;

Reference yield:

: 51421-17-1
4-methylbenzylhydrazine

: 1418297-40-1
2-hydroxy-1-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-2-[4-(trifluoromethoxy)phenyl]ethanone

: 1437796-58-1
2-hydroxy-2-[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]-1-[4-(trifluoromethoxy)-phenyl]ethanone

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid / 4 h / 90 °C

2: water; sodium hydroxide / ethanol / 70 °C

3: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 3 h / 0 - 20 °C

4: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1.5 h / -78 °C / Inert atmosphere

5: sodium ethanolate / ethanol / 4 h

6: 4-methylmorpholine N-oxide; osmium(VIII) oxide / acetone; tert-butyl alcohol / 20 °C

7: water; sodium dithionite / N,N-dimethyl-formamide / 1.5 h / 100 °C

With osmium(VIII) oxide; lithium aluminium tetrahydride; sodium dithionite; oxalyl dichloride; water; sodium ethanolate; acetic acid; 4-methylmorpholine N-oxide; sodium hydroxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;