2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl)acetamide

Base Information

Chemical Name:2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl)acetamide
CAS No.:1352063-00-3
Molecular Formula:C₂₃H₂₄Cl₂N₂O₂
Molecular Weight:431.362
Hs Code.:

Synonyms:2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl)acetamide

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Chemical Property of 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl)acetamide

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Technology Process of 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl)acetamide

There total 11 articles about 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1352062-99-7
methyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl)acetate

: 1352063-00-3
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl)acetamide

Guidance literature:: methyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl)acetate; With ammonia; In methanol; at 25 ℃; for 120h; Inert atmosphere; Sealed tube;

With sodium cyanide; In methanol; at 50 ℃; for 72h; Inert atmosphere; Sealed tube;
DOI:10.1021/jm300354j

Reference yield:

: 1352062-87-3
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl)acetic acid

: 1352063-00-3
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 0 - 25 °C

2.1: ammonia / methanol / 120 h / 25 °C / Sealed tube

2.2: 72 h / 50 °C

With thionyl chloride; ammonia; In methanol;

Reference yield:

: C₁₉H₂₀Cl₂O₅S

: 1352063-00-3
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium azide / N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere

2.1: trimethylphosphane / tetrahydrofuran; water / 1 h / 25 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / methanol; water / Inert atmosphere; Reflux

4.1: Chiralcel OD-H / hexane; isopropyl alcohol / Resolution of racemate

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

5.2: 5 h / 0 - 25 °C / Inert atmosphere

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

7.1: sodium periodate; ruthenium(III) trichloride hydrate / tetrachloromethane; water; acetonitrile / 3 h / 25 °C / Inert atmosphere

8.1: thionyl chloride / 0 - 25 °C / Inert atmosphere

9.1: ammonia / methanol / 120 h / 25 °C / Inert atmosphere; Sealed tube

9.2: 72 h / 50 °C / Inert atmosphere; Sealed tube

With sodium periodate; thionyl chloride; sodium azide; ruthenium(III) trichloride hydrate; ammonia; sodium hydride; sodium hydrogencarbonate; lithium hexamethyldisilazane; trimethylphosphane; In tetrahydrofuran; methanol; tetrachloromethane; hexane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; mineral oil;
DOI:10.1021/jm300354j