2-(3-Fluorophenylamino)thiazole

Base Information

• Chemical Name: 2-(3-Fluorophenylamino)thiazole
• CAS No.: 496052-56-3
• Molecular Formula: C₉H₇FN₂S
• Molecular Weight: 194.232
• DSSTox Substance ID: DTXSID901299039
• Mol file: 496052-56-3.mol

Synonyms:2-(3-Fluorophenylamino)thiazole;N-(3-fluorophenyl)-1,3-thiazol-2-amine;496052-56-3;2-Thiazolamine, N-(3-fluorophenyl)-;DTXSID901299039;N-(3-Fluorophenyl)-2-thiazolamine;AKOS022843532;2-(3-fluorophenylamino)thiazole, AldrichCPR

Chemical Property of 2-(3-Fluorophenylamino)thiazole

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 194.03139757
• Heavy Atom Count: 13
• Complexity: 168

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)F)NC2=NC=CS2

Technology Process of 2-(3-Fluorophenylamino)thiazole

There total 2 articles about 2-(3-Fluorophenylamino)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-thiazolylamine (96-50-4) + m-fluorophenyl trifluoromethanesulfonate (57606-65-2) → N-(3-fluorophenyl)thiazol-2-amine (496052-56-3)

Guidance literature:

With t-BuBrettPhos; water; palladium diacetate; potassium carbonate; In tert-butyl alcohol; at 110 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol300178j

Reference yield:

1-(3-fluorophenyl)thiourea (458-05-9) + chloroacetaldehyde diethyl acetal (621-62-5) → N-(3-fluorophenyl)thiazol-2-amine (496052-56-3)

Guidance literature:

With hydrogenchloride; In water;

DOI:10.2174/1573406411666141230104536

upstream raw materials:

2-thiazolylamine

m-fluorophenyl trifluoromethanesulfonate

1-(3-fluorophenyl)thiourea

chloroacetaldehyde diethyl acetal