phenylmethyl -4-(1H-indol-3-ylmethyl)-1-<1-(methoxycarbonyl)cyclohexyl>-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate

Base Information

• Chemical Name: phenylmethyl -4-(1H-indol-3-ylmethyl)-1-<1-(methoxycarbonyl)cyclohexyl>-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate
• CAS No.: 144876-71-1
• Molecular Formula: C₃₆H₄₁N₅O₆
• Molecular Weight: 639.751

Synonyms:phenylmethyl -4-(1H-indol-3-ylmethyl)-1-<1-(methoxycarbonyl)cyclohexyl>-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate

Chemical Property of phenylmethyl -4-(1H-indol-3-ylmethyl)-1-<1-(methoxycarbonyl)cyclohexyl>-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate

Chemical Property:

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Technology Process of phenylmethyl -4-(1H-indol-3-ylmethyl)-1-<1-(methoxycarbonyl)cyclohexyl>-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate

There total 6 articles about phenylmethyl -4-(1H-indol-3-ylmethyl)-1-<1-(methoxycarbonyl)cyclohexyl>-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 1-isocyanato-1-cyclohexanecarboxylate (144876-59-5) + phenylmethyl -<2-<<2-amino-3-(1H-indol-3-yl)-1-oxopropyl>amino>-1-phenylethyl>carbamate (144876-62-0) → phenylmethyl -4-(1H-indol-3-ylmethyl)-1-<1-(methoxycarbonyl)cyclohexyl>-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate (144876-71-1)

Guidance literature:

In tetrahydrofuran; toluene; at 80 - 100 ℃; for 16h;

DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

1-aminocyclohexane carboxylic acid (2756-85-6) → phenylmethyl -4-(1H-indol-3-ylmethyl)-1-<1-(methoxycarbonyl)cyclohexyl>-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate (144876-71-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / SOCl₂ / 4 h / Heating

2: 32 percent / NEt₃ / CH₂Cl₂ / 25 °C

3: 87 percent / toluene; tetrahydrofuran / 16 h / 80 - 100 °C

With thionyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

methyl 1-aminocyclohexanecarboxylate (4507-57-7) → phenylmethyl -4-(1H-indol-3-ylmethyl)-1-<1-(methoxycarbonyl)cyclohexyl>-2,5-dioxo-8-phenyl-1,3,6,9-tetraazadecan-10-oate (144876-71-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 32 percent / NEt₃ / CH₂Cl₂ / 25 °C

2: 87 percent / toluene; tetrahydrofuran / 16 h / 80 - 100 °C

With triethylamine; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1016/S0040-4020(01)86596-0

upstream raw materials:

methyl 1-isocyanato-1-cyclohexanecarboxylate

phenylmethyl -<2-<<2-amino-3-(1H-indol-3-yl)-1-oxopropyl>amino>-1-phenylethyl>carbamate

1-aminocyclohexane carboxylic acid

methyl 1-aminocyclohexanecarboxylate

Downstream raw materials:

phenylmethyl -<2-<<3-(1H-indol-3-yl)-2-<(4-oxo-3-oxa-1-azaspiro<4.5>dec-1-en-2-yl)amino>-1-oxopropyl>amino>-1-phenylethyl>carbamate

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