ethyl 9,9-bis(4-fluorophenyl)-5-hydroxy-8-(2-methyl-2H-tetrazol-5-yl)-3-oxo-6,8-nonadienoate

Base Information

Chemical Name:ethyl 9,9-bis(4-fluorophenyl)-5-hydroxy-8-(2-methyl-2H-tetrazol-5-yl)-3-oxo-6,8-nonadienoate
CAS No.:130200-55-4
Molecular Formula:C₂₅H₂₄F₂N₄O₄
Molecular Weight:482.487
Hs Code.:

Synonyms:ethyl 9,9-bis(4-fluorophenyl)-5-hydroxy-8-(2-methyl-2H-tetrazol-5-yl)-3-oxo-6,8-nonadienoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 9,9-bis(4-fluorophenyl)-5-hydroxy-8-(2-methyl-2H-tetrazol-5-yl)-3-oxo-6,8-nonadienoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl 9,9-bis(4-fluorophenyl)-5-hydroxy-8-(2-methyl-2H-tetrazol-5-yl)-3-oxo-6,8-nonadienoate

There total 7 articles about ethyl 9,9-bis(4-fluorophenyl)-5-hydroxy-8-(2-methyl-2H-tetrazol-5-yl)-3-oxo-6,8-nonadienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 118875-18-6
ethyl 2-cyano-3,3-bis(4-fluorophenyl)-2-propenoate

: 130200-55-4
ethyl 9,9-bis(4-fluorophenyl)-5-hydroxy-8-(2-methyl-2H-tetrazol-5-yl)-3-oxo-6,8-nonadienoate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) azidotri-n-butylstannane, 2.) aq. KF, 48percent HBF₄ / 1.) toluene, reflux, 20 h, 2.) Et₂O, 16 h

2: 1.) NaH / 1.) benzene, mineral oil, 45 deg C, 30 min, 2.) 40-45 deg C, 4 d

3: diisopropylaluminum hydride (Dibal-H) / CH₂Cl₂ / 2.5 h / -78 °C

4: pyridinium chlorochromate (PCC) / CH₂Cl₂ / 16 h / Ambient temperature

5: 90.5 percent / benzene / 0.5 h / Heating

With potassium fluoride; tetrafluoroboric acid; sodium hydride; diisopropyl aluminium hydride; pyridinium chlorochromate; azido tributyltin (IV); In dichloromethane; benzene;
DOI:10.1021/jm00173a013

Reference yield:

: 3,3-bis(4-fluorophenyl)-2-(2-methyl-2H-tetrazol-5-yl)-2-propenol

: 130200-55-4
ethyl 9,9-bis(4-fluorophenyl)-5-hydroxy-8-(2-methyl-2H-tetrazol-5-yl)-3-oxo-6,8-nonadienoate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium chlorochromate (PCC) / CH₂Cl₂ / 16 h / Ambient temperature

2: 90.5 percent / benzene / 0.5 h / Heating

With pyridinium chlorochromate; In dichloromethane; benzene;
DOI:10.1021/jm00173a013

Reference yield:

: 118875-19-7
ethyl 3,3-bis(4-fluorophenyl)-2-(1H-tetrazol-5-yl)-2-propenoate

: 130200-55-4
ethyl 9,9-bis(4-fluorophenyl)-5-hydroxy-8-(2-methyl-2H-tetrazol-5-yl)-3-oxo-6,8-nonadienoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) benzene, mineral oil, 45 deg C, 30 min, 2.) 40-45 deg C, 4 d

2: diisopropylaluminum hydride (Dibal-H) / CH₂Cl₂ / 2.5 h / -78 °C

3: pyridinium chlorochromate (PCC) / CH₂Cl₂ / 16 h / Ambient temperature

4: 90.5 percent / benzene / 0.5 h / Heating

With sodium hydride; diisopropyl aluminium hydride; pyridinium chlorochromate; In dichloromethane; benzene;
DOI:10.1021/jm00173a013