C₁₉H₁₈N₄O

Base Information

Chemical Name:C₁₉H₁₈N₄O
CAS No.:1429617-57-1
Molecular Formula:C₁₉H₁₈N₄O
Molecular Weight:318.378
Hs Code.:

C<sub>19</sub>H<sub>18</sub>N<sub>4</sub>O

Synonyms:C₁₉H₁₈N₄O

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Chemical Property of C₁₉H₁₈N₄O

Chemical Property:

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Technology Process of C₁₉H₁₈N₄O

There total 5 articles about C₁₉H₁₈N₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.7%

: 1429618-01-8
4-methyl-3-(pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzoic acid

: 75-31-0
isopropylamine

: 1429617-57-1
C₁₉H₁₈N₄O

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1021/jm301824k

Reference yield:

: 1429617-97-9
methyl 4-methyl-3-(pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzoate

: 1429617-57-1
C₁₉H₁₈N₄O

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol / 6 h / 50 °C

1.2: pH 4

2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 6 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane;
DOI:10.1021/jm301824k

Reference yield:

: 90347-66-3
methyl 3-iodo-4-methylbenzoate

: 1429617-57-1
C₁₉H₁₈N₄O

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / ethyl acetate / 20 °C / Inert atmosphere

2.1: potassium carbonate; methanol / 0.08 h / 20 °C

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 80 °C / Inert atmosphere

4.1: sodium hydroxide / methanol / 6 h / 50 °C

4.2: pH 4

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 6 h / 20 °C

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; ethyl acetate; 1.1: |Sonogashira Cross-Coupling / 3.1: |Sonogashira Cross-Coupling;
DOI:10.1021/jm301824k