N-(4-(benzo[d]thiazol-2-yl)-3-hydroxybenzyl)-5-(2-(1-(3-hydroxyphenyl)-4,4-dimethyl-2,6,7-trioxabicyclo[3.2.0]heptan-5-yl)-2-methylpropoxy)pentanamide

Base Information

Chemical Name:N-(4-(benzo[d]thiazol-2-yl)-3-hydroxybenzyl)-5-(2-(1-(3-hydroxyphenyl)-4,4-dimethyl-2,6,7-trioxabicyclo[3.2.0]heptan-5-yl)-2-methylpropoxy)pentanamide
CAS No.:949913-13-7
Molecular Formula:C₃₅H₄₀N₂O₇S
Molecular Weight:632.778
Hs Code.:

Synonyms:N-(4-(benzo[d]thiazol-2-yl)-3-hydroxybenzyl)-5-(2-(1-(3-hydroxyphenyl)-4,4-dimethyl-2,6,7-trioxabicyclo[3.2.0]heptan-5-yl)-2-methylpropoxy)pentanamide

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Chemical Property of N-(4-(benzo[d]thiazol-2-yl)-3-hydroxybenzyl)-5-(2-(1-(3-hydroxyphenyl)-4,4-dimethyl-2,6,7-trioxabicyclo[3.2.0]heptan-5-yl)-2-methylpropoxy)pentanamide

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Technology Process of N-(4-(benzo[d]thiazol-2-yl)-3-hydroxybenzyl)-5-(2-(1-(3-hydroxyphenyl)-4,4-dimethyl-2,6,7-trioxabicyclo[3.2.0]heptan-5-yl)-2-methylpropoxy)pentanamide

There total 4 articles about N-(4-(benzo[d]thiazol-2-yl)-3-hydroxybenzyl)-5-(2-(1-(3-hydroxyphenyl)-4,4-dimethyl-2,6,7-trioxabicyclo[3.2.0]heptan-5-yl)-2-methylpropoxy)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 949913-12-6
N-(4-(benzo[d]thiazol-2-yl)-3-hydroxybenzyl)-5-(2-(2-(3-hydroxyphenyl)-4,4-dimethyl-4,5-dihydrofuran-3-yl)-2-methylpropoxy)pentanamide

: 949913-13-7
N-(4-(benzo[d]thiazol-2-yl)-3-hydroxybenzyl)-5-(2-(1-(3-hydroxyphenyl)-4,4-dimethyl-2,6,7-trioxabicyclo[3.2.0]heptan-5-yl)-2-methylpropoxy)pentanamide

Guidance literature:: With oxygen; 5,15,10,20-tetraphenylporphyrin; In dichloromethane; at 0 ℃; for 1h; Irradiation;
DOI:10.1016/j.tet.2012.04.078

Reference yield:

: 3-(7-ethoxycarbonyl-1,1-dimethyl-3-oxaheptyl)-3-hydroxy-2-(3-methoxyphenyl)-4,4-dimethyl-2,3,4,5-tetrahydrofuran

: 949913-13-7
N-(4-(benzo[d]thiazol-2-yl)-3-hydroxybenzyl)-5-(2-(1-(3-hydroxyphenyl)-4,4-dimethyl-2,6,7-trioxabicyclo[3.2.0]heptan-5-yl)-2-methylpropoxy)pentanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine; thionyl chloride / dichloromethane / 3 h / 0 °C / Inert atmosphere

2.1: sodium thiomethoxide / N,N-dimethyl-formamide / 2 h / 140 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

3.3: Inert atmosphere

4.1: triethylamine / acetonitrile / 1 h / 20 °C / Inert atmosphere

5.1: triethylamine / acetonitrile / 5 h / 20 °C / Inert atmosphere

6.1: sodium thiomethoxide / N,N-dimethyl-formamide / 1 h / 140 °C / Inert atmosphere

6.2: Inert atmosphere

7.1: oxygen; 5,15,10,20-tetraphenylporphyrin / dichloromethane / 1 h / 0 °C / Irradiation

With pyridine; 1H-imidazole; thionyl chloride; oxygen; 5,15,10,20-tetraphenylporphyrin; triethylamine; sodium thiomethoxide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2012.04.078

Reference yield:

: 594859-80-0
4-(7-carboxy-1,1-dimethyl-3-oxaheptyl )-5-(3-hydroxyphenyl)-3,3-dimethyl-2,3-dihydrofuran

: 949913-13-7
N-(4-(benzo[d]thiazol-2-yl)-3-hydroxybenzyl)-5-(2-(1-(3-hydroxyphenyl)-4,4-dimethyl-2,6,7-trioxabicyclo[3.2.0]heptan-5-yl)-2-methylpropoxy)pentanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: triethylamine / acetonitrile / 1 h / 20 °C / Inert atmosphere

3.1: triethylamine / acetonitrile / 5 h / 20 °C / Inert atmosphere

4.1: sodium thiomethoxide / N,N-dimethyl-formamide / 1 h / 140 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: oxygen; 5,15,10,20-tetraphenylporphyrin / dichloromethane / 1 h / 0 °C / Irradiation

With 1H-imidazole; oxygen; 5,15,10,20-tetraphenylporphyrin; triethylamine; sodium thiomethoxide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2012.04.078