3-ethyl 5-methyl 2-fluoro-6-methyl-4-(p-tolyl)pyridine-3,5-dicarboxylate

Base Information

Chemical Name:3-ethyl 5-methyl 2-fluoro-6-methyl-4-(p-tolyl)pyridine-3,5-dicarboxylate
CAS No.:1418718-65-6
Molecular Formula:C₁₈H₁₈FNO₄
Molecular Weight:331.344
Hs Code.:

Synonyms:3-ethyl 5-methyl 2-fluoro-6-methyl-4-(p-tolyl)pyridine-3,5-dicarboxylate

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Chemical Property of 3-ethyl 5-methyl 2-fluoro-6-methyl-4-(p-tolyl)pyridine-3,5-dicarboxylate

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Technology Process of 3-ethyl 5-methyl 2-fluoro-6-methyl-4-(p-tolyl)pyridine-3,5-dicarboxylate

There total 3 articles about 3-ethyl 5-methyl 2-fluoro-6-methyl-4-(p-tolyl)pyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1418717-47-1
3-ethyl 5-methyl 2-amino-6-methyl-4-(p-tolyl)pyridine-3,5-dicarboxylate

: 1418718-65-6
3-ethyl 5-methyl 2-fluoro-6-methyl-4-(p-tolyl)pyridine-3,5-dicarboxylate

Guidance literature:: With pyridine hydrofluoride; sodium nitrite; In tetrahydrofuran; at 0 - 20 ℃; under 760.051 Torr;

Reference yield:

: 1418717-44-8
3-ethyl 5-methyl 2-amino-6-methyl-4-(p-tolyl)-1,4-dihydropyridine-3,5-dicarboxylate

: 1418718-65-6
3-ethyl 5-methyl 2-fluoro-6-methyl-4-(p-tolyl)pyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1.5 h / 20 °C / 760.05 Torr

2: sodium nitrite; pyridine hydrofluoride / tetrahydrofuran / 0 - 20 °C / 760.05 Torr

With pyridine hydrofluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium nitrite; In tetrahydrofuran; dichloromethane;

Reference yield:

: 107634-95-7
methyl 2-(4-methylbenzylidene)-3-oxobutanoate

: 1418718-65-6
3-ethyl 5-methyl 2-fluoro-6-methyl-4-(p-tolyl)pyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine / isopropyl alcohol / 760.05 Torr / Reflux

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1.5 h / 20 °C / 760.05 Torr

3: sodium nitrite; pyridine hydrofluoride / tetrahydrofuran / 0 - 20 °C / 760.05 Torr

With 4-methyl-morpholine; pyridine hydrofluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium nitrite; In tetrahydrofuran; dichloromethane; isopropyl alcohol;