(R)-3-Phenyl-nonanoic acid (2-fluoro-benzyl)-((R)-1-hydroxymethyl-propyl)-amide

Base Information

• Chemical Name: (R)-3-Phenyl-nonanoic acid (2-fluoro-benzyl)-((R)-1-hydroxymethyl-propyl)-amide
• CAS No.: 152529-49-2
• Molecular Formula: C₂₆H₃₆FNO₂
• Molecular Weight: 413.576
• Mol file: 152529-49-2.mol

Synonyms:(R)-3-Phenyl-nonanoic acid (2-fluoro-benzyl)-((R)-1-hydroxymethyl-propyl)-amide

Chemical Property of (R)-3-Phenyl-nonanoic acid (2-fluoro-benzyl)-((R)-1-hydroxymethyl-propyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-Phenyl-nonanoic acid (2-fluoro-benzyl)-((R)-1-hydroxymethyl-propyl)-amide

There total 4 articles about (R)-3-Phenyl-nonanoic acid (2-fluoro-benzyl)-((R)-1-hydroxymethyl-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(E)-N-(2-Fluoro-benzyl)-N-((R)-1-hydroxymethyl-propyl)-3-phenyl-acrylamide (152529-41-4) → (R)-3-Phenyl-nonanoic acid (2-fluoro-benzyl)-((R)-1-hydroxymethyl-propyl)-amide (152529-49-2)

Guidance literature:

In diethyl ether; at 0 ℃; for 4h;

DOI:10.1016/S0957-4166(00)80345-6

Reference yield:

2-fluorobenzyl chloride (345-35-7) → (R)-3-Phenyl-nonanoic acid (2-fluoro-benzyl)-((R)-1-hydroxymethyl-propyl)-amide (152529-49-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / 2 h / 90 °C

2: 87 percent / aq. Na₂CO₃ / CH₂Cl₂ / 3 h / Ambient temperature

3: 1.) Mg / 1,) l'ether, 0 deg C, 1 h, 2.) l'ether, 0 deg C, 3 h

With sodium carbonate; magnesium; In dichloromethane;

Reference yield:

(R)-(-)-N-(2-fluorobenzyl)-2-aminobutan-1-ol (152529-39-0,626223-94-7) → (R)-3-Phenyl-nonanoic acid (2-fluoro-benzyl)-((R)-1-hydroxymethyl-propyl)-amide (152529-49-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / aq. Na₂CO₃ / CH₂Cl₂ / 3 h / Ambient temperature

2: 1.) Mg / 1,) l'ether, 0 deg C, 1 h, 2.) l'ether, 0 deg C, 3 h

With sodium carbonate; magnesium; In dichloromethane;

upstream raw materials:

1-bromo-hexane

(E)-N-(2-Fluoro-benzyl)-N-((R)-1-hydroxymethyl-propyl)-3-phenyl-acrylamide

2-fluorobenzyl chloride

(R)-(-)-N-(2-fluorobenzyl)-2-aminobutan-1-ol