ethyl [4-(4-{[(2-anilino-1,3-oxazol-5-yl)carbonyl]amino}phenyl)cyclohexyl]acetate

Base Information

Chemical Name:ethyl [4-(4-{[(2-anilino-1,3-oxazol-5-yl)carbonyl]amino}phenyl)cyclohexyl]acetate
CAS No.:959967-28-3
Molecular Formula:C₂₆H₂₉N₃O₄
Molecular Weight:447.534
Hs Code.:

Synonyms:ethyl [4-(4-{[(2-anilino-1,3-oxazol-5-yl)carbonyl]amino}phenyl)cyclohexyl]acetate

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Chemical Property of ethyl [4-(4-{[(2-anilino-1,3-oxazol-5-yl)carbonyl]amino}phenyl)cyclohexyl]acetate

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Technology Process of ethyl [4-(4-{[(2-anilino-1,3-oxazol-5-yl)carbonyl]amino}phenyl)cyclohexyl]acetate

There total 4 articles about ethyl [4-(4-{[(2-anilino-1,3-oxazol-5-yl)carbonyl]amino}phenyl)cyclohexyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 2-anilino-1,3-oxazole-5-carboxylic acid

: 959967-30-7
ethyl [4-(4-aminophenyl)cyclohexyl]acetate

: 959967-28-3
ethyl [4-(4-{[(2-anilino-1,3-oxazol-5-yl)carbonyl]amino}phenyl)cyclohexyl]acetate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 411238-92-1
ethyl 2-(4-phenylcyclohexyl)acetate

: 959967-28-3
ethyl [4-(4-{[(2-anilino-1,3-oxazol-5-yl)carbonyl]amino}phenyl)cyclohexyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; nitric acid / tetrachloromethane / 16 h / 5 - 20 °C

2: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With sulfuric acid; hydrogen; nitric acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrachloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 959967-24-9
ethyl 2-anilino-1,3-oxazole-5-carboxylate

: 959967-28-3
ethyl [4-(4-{[(2-anilino-1,3-oxazol-5-yl)carbonyl]amino}phenyl)cyclohexyl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran; water / 1 h / 70 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;