N-(4-(3-bromoanilino)quinazolin-6-yl)-3-(4-methylpiperazin-1-yl)propanamide

Base Information

Chemical Name:N-(4-(3-bromoanilino)quinazolin-6-yl)-3-(4-methylpiperazin-1-yl)propanamide
CAS No.:1233953-85-9
Molecular Formula:C₂₂H₂₅BrN₆O
Molecular Weight:469.384
Hs Code.:

Synonyms:N-(4-(3-bromoanilino)quinazolin-6-yl)-3-(4-methylpiperazin-1-yl)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-(3-bromoanilino)quinazolin-6-yl)-3-(4-methylpiperazin-1-yl)propanamide

Chemical Property:

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Technology Process of N-(4-(3-bromoanilino)quinazolin-6-yl)-3-(4-methylpiperazin-1-yl)propanamide

There total 6 articles about N-(4-(3-bromoanilino)quinazolin-6-yl)-3-(4-methylpiperazin-1-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 109-01-3
1-methyl-piperazine

: 1233953-80-4
N-(4-((3-bromophenyl)amino)quinazolin-6-yl)-3-chloropropanamide

: 1233953-85-9
N-(4-(3-bromoanilino)quinazolin-6-yl)-3-(4-methylpiperazin-1-yl)propanamide

Guidance literature:: 1-methyl-piperazine; N-(4-((3-bromophenyl)amino)quinazolin-6-yl)-3-chloropropanamide; With potassium iodide; In ethanol; Reflux;

With potassium hydroxide; In ethanol; at 0 ℃;
DOI:10.1021/jm201507x

Reference yield: 70.0%

: 1233953-85-9
N-(4-(3-bromoanilino)quinazolin-6-yl)-3-(4-methylpiperazin-1-yl)propanamide

Guidance literature:

Reference yield:

: 17420-30-3
5-nitroanthranilonitrile

: 1233953-85-9
N-(4-(3-bromoanilino)quinazolin-6-yl)-3-(4-methylpiperazin-1-yl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / Reflux

2.1: thionyl chloride / 1,4-dioxane / Reflux

2.2: 60 °C

3.1: iron; acetic acid / ethanol; water / Reflux

4.1: 5 h / 50 °C

5.1: potassium iodide / ethanol / Reflux

5.2: 0 °C

With thionyl chloride; sulfuric acid; iron; acetic acid; potassium iodide; In 1,4-dioxane; ethanol; water;
DOI:10.1021/jm201507x