1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid [1-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide

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Chemical Name:1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid [1-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide
CAS No.:1613022-28-8
Molecular Formula:C₂₂H₂₁FN₆O
Molecular Weight:404.447
Hs Code.:

Synonyms:1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid [1-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide

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Chemical Property of 1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid [1-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide

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Technology Process of 1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid [1-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide

There total 8 articles about 1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid [1-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1152535-34-6
1–(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid

: 1-(3-methyl-pyrrolo[1,2-a]pyrazin-1-yl)-pyrrolidin-3-ylamine dihydrochloride salt

: 1613022-28-8
1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid [1-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide

Guidance literature:: With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dimethyl sulfoxide; for 0.5h;

Reference yield:

: 35302-72-8
pyrrol-2-yl trichloromethyl ketone

: 1613022-28-8
1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid [1-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide

Guidance literature:: Multi-step reaction with 6 steps

1: acetone / 20 °C

2: ammonium acetate / acetic acid / 48 h / 160 °C / Sealed tube

3: trichlorophosphate / 3 h / 105 °C

4: N-ethyl-N,N-diisopropylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate / 15 h / 110 °C

5: hydrogenchloride / methanol; 1,4-dioxane

6: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / dimethyl sulfoxide / 0.5 h

With hydrogenchloride; ammonium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; 1-butyl-3-methylimidazolium Tetrafluoroborate; trichlorophosphate; In 1,4-dioxane; methanol; acetic acid; dimethyl sulfoxide; acetone;

Reference yield:

: 352-34-1
4-fluoro-1-iodobenzene

: 1613022-28-8
1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid [1-(3-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; potassium carbonate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / toluene / 2 h / 110 °C

2: sodium hydroxide / water; ethanol / 1 h / 50 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / dimethyl sulfoxide / 0.5 h

With copper(l) iodide; potassium carbonate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In ethanol; water; dimethyl sulfoxide; toluene;