[trans-4-({1-[5-(5,6-difluoro-1H-benzimidazol-2-yl)pyridin-2-yl]piperidin-4-yl}oxy)cyclohexyl]acetic acid

Base Information

Chemical Name:[trans-4-({1-[5-(5,6-difluoro-1H-benzimidazol-2-yl)pyridin-2-yl]piperidin-4-yl}oxy)cyclohexyl]acetic acid
CAS No.:1415570-92-1
Molecular Formula:C₂₅H₂₈F₂N₄O₃
Molecular Weight:470.519
Hs Code.:

Synonyms:[trans-4-({1-[5-(5,6-difluoro-1H-benzimidazol-2-yl)pyridin-2-yl]piperidin-4-yl}oxy)cyclohexyl]acetic acid

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Chemical Property of [trans-4-({1-[5-(5,6-difluoro-1H-benzimidazol-2-yl)pyridin-2-yl]piperidin-4-yl}oxy)cyclohexyl]acetic acid

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Technology Process of [trans-4-({1-[5-(5,6-difluoro-1H-benzimidazol-2-yl)pyridin-2-yl]piperidin-4-yl}oxy)cyclohexyl]acetic acid

There total 10 articles about [trans-4-({1-[5-(5,6-difluoro-1H-benzimidazol-2-yl)pyridin-2-yl]piperidin-4-yl}oxy)cyclohexyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₃₀F₂N₄O₃

: 1415570-92-1
[trans-4-({1-[5-(5,6-difluoro-1H-benzimidazol-2-yl)pyridin-2-yl]piperidin-4-yl}oxy)cyclohexyl]acetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2019.03.039

Reference yield:

: 1415573-04-4
5,6-difluoro-2-(6-fluoropyridin-3-yl)-1H-benzimidazole

: 1415573-12-4
methyl 2-((1r,4r)-4-(piperidin-4-yloxy)cyclohexyl) acetate

: 1415570-92-1
[trans-4-({1-[5-(5,6-difluoro-1H-benzimidazol-2-yl)pyridin-2-yl]piperidin-4-yl}oxy)cyclohexyl]acetic acid

Guidance literature:: 5,6-difluoro-2-(6-fluoropyridin-3-yl)-1H-benzimidazole; methyl 2-((1r,4r)-4-(piperidin-4-yloxy)cyclohexyl) acetate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 65 ℃; for 1h;

With hydrogenchloride; In water; pH=6.5 - 7;

Reference yield:

: 626-64-2,157061-69-3
pyridin-4-ol

: 1415570-92-1
[trans-4-({1-[5-(5,6-difluoro-1H-benzimidazol-2-yl)pyridin-2-yl]piperidin-4-yl}oxy)cyclohexyl]acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 55 °C / Inert atmosphere

2.1: hydrogen; acetic acid / Rh/AI₂O₃ / 80 °C / 60006 Torr

3.1: chloro-trimethyl-silane; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

3.2: 0.5 h / -65 - 0 °C

4.1: ChiralPak AD / ethanol; carbon dioxide / Resolution of racemate

5.1: hydrogen / 5%-palladium/activated carbon / methanol / 760.05 Torr

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 65 °C

6.2: pH 6.5 - 7

With chloro-trimethyl-silane; di-isopropyl azodicarboxylate; water; hydrogen; acetic acid; triethylamine; triphenylphosphine; sodium hydroxide; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; ethanol; carbon dioxide;