2-NITRO-4-TRIFLUOROMETHYL-BIPHENYL

Base Information

• Chemical Name: 2-NITRO-4-TRIFLUOROMETHYL-BIPHENYL
• CAS No.: 2613-38-9
• Molecular Formula: C13H8 F3 N O2
• Molecular Weight: 267.2033296
• Hs Code.: 2904909090
• Mol file: 2613-38-9.mol

Synonyms:Biphenyl,2-nitro-4-(trifluoromethyl)- (6CI,8CI); 2-Nitro-4-trifluoromethylbiphenyl

Chemical Property of 2-NITRO-4-TRIFLUOROMETHYL-BIPHENYL

Chemical Property:

• Vapor Pressure: 0.00151mmHg at 25°C
• Refractive Index: 1.535
• Boiling Point: 305.2°C at 760 mmHg
• Flash Point: 138.4°C
• PSA: 45.82000
• Density: 1.335g/cm³
• LogP: 4.80380

Purity/Quality:

99%min ^*data from raw suppliers

2-NITRO-4-TRIFLUOROMETHYL-BIPHENYL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-NITRO-4-TRIFLUOROMETHYL-BIPHENYL

There total 6 articles about 2-NITRO-4-TRIFLUOROMETHYL-BIPHENYL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-chloro-3-nitro-5-trifluoromethylbenzene (121-17-5) + phenylboronic acid (98-80-6) → 2-nitro-4-trifluoromethylbiphenyl (2613-38-9)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); N,N,N',N'-tetra(diphenylphosphinomethyl)benzene-1,3-diamine; potassium carbonate; In N,N-dimethyl acetamide; at 130 ℃; for 20h; Time; Concentration; Inert atmosphere; Schlenk technique;

DOI:10.1007/s10562-013-1028-0

Reference yield: 77.0%

2-nitro-4-trifluoromethylbenzoic acid (320-94-5) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 2-nitro-4-trifluoromethylbiphenyl (2613-38-9)

Guidance literature:

With dipotassium peroxodisulfate; silver sulfate; In acetonitrile; at 120 ℃; for 24h; Glovebox; Schlenk technique; Sealed tube; Inert atmosphere;

DOI:10.1002/anie.201408630

Reference yield: 76.2%

1-bromo-4-trifluoromethyl-2-nitrobenzene (349-03-1) + phenylboronic acid (98-80-6) → 2-nitro-4-trifluoromethylbiphenyl (2613-38-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ol503459s

upstream raw materials:

4-trifluoromethyl-2-nitroaniline

benzene

2-chloro-3-nitro-5-trifluoromethylbenzene

phenylboronic acid

Refernces

• 1、 Guo, Fei-Chen,Zhou, Rong,Jiang, Zhi-Jie,Wang, Wei,Fu, Hai-Yan,Zheng, Xue-Li,Chen, Hua,Li, Rui-Xiang. "N,N,N′,N′-tetra(diphenylphosphinomethyl)pyridine-2,6-diamine/palladium catalyzed Suzuki-Miyaura coupling of aryl and heteroaryl halides". . p. 87 - 90. Retrieved 2015/04/14.
• 2、 Kan, Jian,Huang, Shijun,Lin, Jin,Zhang, Min,Su, Weiping. "Silver-catalyzed arylation of (hetero)arenes by oxidative decarboxylation of aromatic carboxylic acids". supporting information. p. 2199 - 2203. Retrieved 2015/02/19.