3-<(3,4-dichlorophenyl)methyl>-1,2-dihydro-2-oxo-1(2H)-quinazolineacetic acid

Base Information

Chemical Name:3-<(3,4-dichlorophenyl)methyl>-1,2-dihydro-2-oxo-1(2H)-quinazolineacetic acid
CAS No.:133166-73-1
Molecular Formula:C₁₇H₁₄Cl₂N₂O₃
Molecular Weight:365.216
Hs Code.:

Synonyms:3-<(3,4-dichlorophenyl)methyl>-1,2-dihydro-2-oxo-1(2H)-quinazolineacetic acid

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Chemical Property of 3-<(3,4-dichlorophenyl)methyl>-1,2-dihydro-2-oxo-1(2H)-quinazolineacetic acid

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Technology Process of 3-<(3,4-dichlorophenyl)methyl>-1,2-dihydro-2-oxo-1(2H)-quinazolineacetic acid

There total 6 articles about 3-<(3,4-dichlorophenyl)methyl>-1,2-dihydro-2-oxo-1(2H)-quinazolineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.8%

: [3-(3,4-Dichloro-benzyl)-2-oxo-3,4-dihydro-2H-quinazolin-1-yl]-acetic acid methyl ester

: 133166-73-1
3-<(3,4-dichlorophenyl)methyl>-1,2-dihydro-2-oxo-1(2H)-quinazolineacetic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; for 1h;
DOI:10.1021/jm00108a038

Reference yield:

: 612-23-7
2-nitrobenzyl chloride

: 133166-73-1
3-<(3,4-dichlorophenyl)methyl>-1,2-dihydro-2-oxo-1(2H)-quinazolineacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / Et₃N / dimethylformamide / 10 h / Ambient temperature

2: 7.9 g / SnCl₂*2H₂O, concd. HCl / ethanol / 4 h

3: dioxane; toluene / 2 h / 100 °C

4: 1.) NaH (80percent dispersion in oil) / 1.) DMF, RT, 2 h, 2.) 1 h

5: 68.8 percent / 2.5 N aq. NaOH / methanol; tetrahydrofuran / 1 h

With hydrogenchloride; sodium hydroxide; sodium hydride; triethylamine; tin(ll) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00108a038

Reference yield:

: 2-[(3,4-Dichloro-benzylamino)-methyl]-phenylamine

: 133166-73-1
3-<(3,4-dichlorophenyl)methyl>-1,2-dihydro-2-oxo-1(2H)-quinazolineacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dioxane; toluene / 2 h / 100 °C

2: 1.) NaH (80percent dispersion in oil) / 1.) DMF, RT, 2 h, 2.) 1 h

3: 68.8 percent / 2.5 N aq. NaOH / methanol; tetrahydrofuran / 1 h

With sodium hydroxide; sodium hydride; In tetrahydrofuran; 1,4-dioxane; methanol; toluene;
DOI:10.1021/jm00108a038