N-benzyl-4-methyl-N-(2-methylene-4-trimethylsilanyl-but-3-ynyl)-benzenesulfonamide

Base Information

• Chemical Name: N-benzyl-4-methyl-N-(2-methylene-4-trimethylsilanyl-but-3-ynyl)-benzenesulfonamide
• CAS No.: 438494-50-9
• Molecular Formula: C₂₂H₂₇NO₂SSi
• Molecular Weight: 397.613

Synonyms:N-benzyl-4-methyl-N-(2-methylene-4-trimethylsilanyl-but-3-ynyl)-benzenesulfonamide

Chemical Property of N-benzyl-4-methyl-N-(2-methylene-4-trimethylsilanyl-but-3-ynyl)-benzenesulfonamide

Chemical Property:

Purity/Quality:

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Technology Process of N-benzyl-4-methyl-N-(2-methylene-4-trimethylsilanyl-but-3-ynyl)-benzenesulfonamide

There total 2 articles about N-benzyl-4-methyl-N-(2-methylene-4-trimethylsilanyl-but-3-ynyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-benzyl-N-(2-bromo-allyl)-4-methyl-benzenesulfonamide (438494-49-6) + trimethylsilylacetylene (1066-54-2) → N-benzyl-4-methyl-N-(2-methylene-4-trimethylsilanyl-but-3-ynyl)-benzenesulfonamide (438494-50-9)

Guidance literature:

With copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride;

DOI:10.1021/jo020004h

Reference yield:

N-benzyl-p-toluenesulfonamide (1576-37-0) → N-benzyl-4-methyl-N-(2-methylene-4-trimethylsilanyl-but-3-ynyl)-benzenesulfonamide (438494-50-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / NaH

2: 88 percent / CuI / PdCl₂(PPh₃)3

With copper(l) iodide; sodium hydride; bis(triphenylphosphine)palladium(II) dichloride;

DOI:10.1021/jo020004h

Reference yield: 98.0%

N-benzyl-4-methyl-N-(2-methylene-4-trimethylsilanyl-but-3-ynyl)-benzenesulfonamide (438494-50-9) → N-benzyl-4-methyl-N-(2-methylene-but-3-ynyl)-benzenesulfonamide (438494-51-0)

Guidance literature:

With tetrabutyl ammonium fluoride;

DOI:10.1021/jo020004h

upstream raw materials:

N-benzyl-N-(2-bromo-allyl)-4-methyl-benzenesulfonamide

trimethylsilylacetylene

N-benzyl-p-toluenesulfonamide

Downstream raw materials:

N-benzyl-4-methyl-N-(2-methylene-but-3-ynyl)-benzenesulfonamide

2-{[benzyl(4-methylphenyl)-sulfonamido]methyl}-2-ethynyloxirane

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