ethyl 2-(((2-(4-aminophenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate

Base Information

Chemical Name:ethyl 2-(((2-(4-aminophenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate
CAS No.:1235451-07-6
Molecular Formula:C₂₅H₂₇N₇O₃S
Molecular Weight:505.6
Hs Code.:

Synonyms:ethyl 2-(((2-(4-aminophenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate

Suppliers and Price of ethyl 2-(((2-(4-aminophenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 2-(((2-(4-aminophenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 2-(((2-(4-aminophenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate

There total 21 articles about ethyl 2-(((2-(4-aminophenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1235451-08-7
ethyl 2-(((2-(4-acetamidophenyl)-4-morpholinothieno-[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate

: 1235451-07-6
ethyl 2-(((2-(4-aminophenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate

Guidance literature:: ethyl 2-(((2-(4-acetamidophenyl)-4-morpholinothieno-[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate; With hydrogenchloride; water; In tetrahydrofuran; at 40 ℃; for 2h;

With sodium hydrogencarbonate; In tetrahydrofuran; water;

Reference yield:

: 22288-78-4
Methyl 3-aminothiophene-2-carboxylate

: 1235451-07-6
ethyl 2-(((2-(4-aminophenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: 2 h / 190 °C

1.2: Heating

2.1: trichlorophosphate / 10 h / Reflux

3.1: methanol / 1 h / 20 °C

4.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1 h / -78 °C

4.2: 11 h / -78 - 20 °C

5.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

6.1: triphenylphosphine; N-Bromosuccinimide / dichloromethane / 3 h / 25 °C

7.1: ethanol / 1 h / Reflux

8.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

9.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 2 h / 120 °C / Inert atmosphere; Microwave irradiation

10.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 40 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; N-Bromosuccinimide; water; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium diisopropyl amide; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 16234-14-3
2,4-dichlorothieno[3,2-d]pyrimidine

: 1235451-07-6
ethyl 2-(((2-(4-aminophenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: methanol / 1 h / 20 °C

2.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 11 h / -78 - 20 °C

3.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

4.1: triphenylphosphine; N-Bromosuccinimide / dichloromethane / 3 h / 25 °C

5.1: ethanol / 1 h / Reflux

6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

7.1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 2 h / 120 °C / Inert atmosphere; Microwave irradiation

8.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 40 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; N-Bromosuccinimide; water; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; toluene; acetonitrile;